65836-72-8
中文名稱
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
英文名稱
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
CAS
65836-72-8
分子式
C11H14ClNO3
分子量
243.69
MOL 文件
65836-72-8.mol
更新日期
2023/09/09 21:38:28
65836-72-8 結(jié)構(gòu)式
基本信息
中文別名
2-氯-N-((34-二甲氧苯基)甲基)乙酰胺
UBA5抑制劑(DKM 2-93)
2-氯-N-(3,4-二甲氧基芐基)乙酰胺
2-氯-N-[(3,4-二甲氧苯基)甲基]乙酰胺
2-氯-N-((3,4-二甲氧苯基)甲基)乙酰胺
乙酰胺,2-氯-N-((3,4-二甲氧苯基)甲基)-
英文別名
DKM 2-93Brn 2857211
CHEMBRDG-BB 9070724
N-(Dimethoxy-3,4 benzyl)-chloroacetamide
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french]
2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide
2-chloro-N-[(3,4-dimethoxyphenyl)methyl]ethanamide
Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-
2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)
物理化學(xué)性質(zhì)
熔點(diǎn)116-118 °C(Solv: carbon tetrachloride (56-23-5))
沸點(diǎn)425.7±45.0 °C(Predicted)
密度1.194±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : ≥ 150 mg/mL (615.54 mM)
酸度系數(shù)(pKa)13.42±0.46(Predicted)
形態(tài)Solid
顏色White to light yellow
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301-H311-H331-H341
防范說明P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)等級(jí)IRRITANT
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-101836 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93 | 65836-72-8 | 50mg | 660元 |
| 2024/11/08 | HY-101836 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93 | 65836-72-8 | 10mM * 1mLin DMSO | 726元 |
| 2024/11/08 | HY-101836 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93 | 65836-72-8 | 100mg | 990元 |
常見問題列表
生物活性
DKM 2-93是相對(duì)選擇性的UBA5抑制劑，IC50值為430 μM。靶點(diǎn)
IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)
體外研究
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively.
體內(nèi)研究
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.