65528-98-5
中文名稱
1-Oleoyl Lysophosphatidic Acid
英文名稱
1-Oleoyl Lysophosphatidic Acid
CAS
65528-98-5
分子式
C21H41O7P
分子量
436.52
MOL 文件
65528-98-5.mol
65528-98-5 結(jié)構(gòu)式
基本信息
英文別名
WRGQSWVCFNIUNZ-GDCKJWNLSA-N1-Oleoyl Lysophosphatidic Acid Exclusive
9-Octadecenoic acid (9Z)-, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester
物理化學(xué)性質(zhì)
沸點(diǎn)581.5±60.0 °C(Predicted)
密度1.103±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 2 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): 3 mg/ml
酸度系數(shù)(pKa)1.82±0.10(Predicted)
形態(tài)Liquid
顏色Colorless to light yellow
常見(jiàn)問(wèn)題列表
生物活性
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) 是一種豐富的溶血磷脂酸種類,由于其對(duì) LPA 受體 (LPA receptors) 的強(qiáng)親和力,具有很高的生物活性。1-Oleoyl lysophosphatidic acid 在大多數(shù)實(shí)驗(yàn)室中常用作 LPA 受體激活的試劑。1-Oleoyl lysophosphatidic acid 可增加 SRE 驅(qū)動(dòng)的 β-galactosidase 的活性。體內(nèi)研究
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) (0.4-2 μg; i.c.v.; 9-week-old male Wistar rats) induces anxiety-like responses in the elevated plus maze (EPM) under novelty conditions.
Animal Model: | 9-week-old male Wistar rats |
Dosage: | 0.4-2 μg |
Administration: | I.c.v. |
Result: | Reduced open arm exploration under novelty conditions and had no effect under habituated conditions in the EPM. |