636-58-8
中文名稱
G-谷氨酸-半胱-三氟乙酸鹽
英文名稱
GAMMA-GLU-CYS TRIFLUOROACETATE SALT
CAS
636-58-8
分子式
C8H14N2O5S
分子量
250.27
MOL 文件
636-58-8.mol
更新日期
2024/06/24 11:40:55
636-58-8 結構式
基本信息
中文別名
谷胱甘肽雜質D谷胱甘肽EP雜質D
Γ-GLU-半胱氨酸
Γ-谷氨酸-半胱氨酸
Γ-谷氨酰-半胱氨酸
谷胱甘肽雜質D(EP)
Γ-L-谷氨酰基-L半胱氨酸
L-Γ-谷氨酰-L-半胱氨酸
G-谷氨酸-半胱-三氟乙酸鹽
5-L-谷氨酰-L-半胱氨酸
英文別名
γ-glu-cysy-Glu-Cys
gaMMa-Glu-Cys
H-g-Glu-Cys-OH
Gamma Glu-L-Cys-OH
H-GLU(CYS-OH)-OH TFA
gamma-glutamylcysteine
γ-L-Glutamyl-L-cysteine
5-L-Glutamyl-L-cysteine
Glutathione Ep Impurity D
所屬類別
生物化工：谷氨酸類衍生物物理化學性質
熔點167℃
沸點592.4±50.0 °C(Predicted)
密度1.436±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度≥ 25mg/mL in Water, ≥ 52 mg/mL in DMSO, ≥ 54.8 mg/mL in EtOH
酸度系數(shù)(pKa)2.21±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
InChIKeyRITKHVBHSGLULN-WHFBIAKZSA-N
常見問題列表
生物活性
Gamma-glutamylcysteine (γ-Glutamylcysteine) 是一種含有半胱氨酸和谷氨酸的二肽，是谷胱甘肽 (GSH) 的前體。Gamma-glutamylcysteine 是谷胱甘肽過氧化物酶 (GPx) 增加 GSH 水平的輔助因子。靶點
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Human Endogenous Metabolite
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體外研究
Co-treatment of Aβ40 oligomers with Gamma-glutamylcysteine (γ-Glutamylcysteine; GGC) at 200 μM increased the activity of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) and leads to significant increases in the levels of the total antioxidant capacity (TAC) and GSH and reduces the GSSG/GSH ratio. Gamma-glutamylcysteine also upregulates the level of the anti-inflammatory cytokine IL-10 and reduced the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes.