成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>634911-80-1

634911-80-1

中文名稱 3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯
英文名稱 3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester
CAS 634911-80-1
分子式 C11H18FNO5
分子量 263.26
MOL 文件 634911-80-1.mol
更新日期 2024/11/15 18:20:32
634911-80-1 結(jié)構(gòu)式 634911-80-1 結(jié)構(gòu)式

基本信息

中文別名
3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯
英文別名
Caspase Inhibitor Boc-D-FMK
Caspase3-Inhibitor Boc-D-FMK
1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-
3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester
Pentanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-5-fluoro-4-oxo-, Methyl ester
BOC-D-FMK (Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester)
所屬類別
有機(jī)原料:羧酸酯及其衍生物

物理化學(xué)性質(zhì)

沸點(diǎn)383.5±37.0 °C(Predicted)
密度1.150
酸度系數(shù)(pKa)10.12±0.46(Predicted)
形態(tài)<31.2°C Solid,>31.2°C Liquid
顏色Light yellow to yellow

常見問題列表

生物活性
Boc-D-FMK 是可滲透細(xì)胞,不可逆的,泛半胱天冬酶 (caspase) 抑制劑。Boc-D-FMK 抑制 TNF-α 誘導(dǎo)的細(xì)胞凋亡的 IC50 值為 39 μM。
靶點(diǎn)

Caspase

體外研究

Apoptosis is a pathway of cell death orchestrated by a family of proteases called caspases. Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC 50 of 39 μM. BocD-fmk at 50 μM prevents genistein-induced apoptosis of p815 cells. Confocal microscopy shows that the release of mitochondrial apoptotic factors is inhibited by BocD-fmk.

體內(nèi)研究

Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after endotoxin challenge. A single injection of Boc-D-FMK results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle.

"634911-80-1" 相關(guān)產(chǎn)品信息