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634911-47-0

中文名稱 BF-168
英文名稱 BF-168
CAS 634911-47-0
分子式 C18H17FN2O2
分子量 312.34
MOL 文件 634911-47-0.mol
634911-47-0 結(jié)構(gòu)式 634911-47-0 結(jié)構(gòu)式

基本信息

中文別名
化合物 T10529
英文別名
BF-168

物理化學(xué)性質(zhì)

沸點511.3±60.0 °C(Predicted)
密度1.258±0.06 g/cm3(Predicted)
儲存條件Store at -20°C,unstable in solution, ready to use.
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4.28±0.42(Predicted)
形態(tài)Solid
顏色White to yellow

常見問題列表

生物活性
BF-168 是 PET 的候選探針,能夠特異性識別神經(jīng)和彌漫性斑塊,其對 Aβ1-42 的 Ki 值為 6.4 nM。
靶點

Ki: 6.4 nM (Aβ1-42).

體外研究

BF-168, a styrylbenzoxazole derivative, is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques, with a K i of 6.4 nM for Aβ1-42.

體內(nèi)研究

Intravenous injection of BF-168 in PS1/APP and APP23 transgenic mice result in specific in vivo labeling to both compact and diffuse amyloid deposits in the brain. In addition, 18 F-radiolabeled BF-168 demonstrates abundant initial brain uptake (3.9% injected dose/gm at 2 min after injection) and fast clearance (t 1/2 =24.7 min) after intravenous administration in normal mice. Furthermore, autoradiograms of brain sections from APP23 transgenic mice at 180 min after intravenous injection of [ 18 F]BF-168 shows selective labeling of brain amyloid deposits with little nonspecific binding.

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