Anitrazafen is a topically effective antiinflammatory agent. The disposition of ¹⁴ C in normal and in bile-duct cannulated rats after oral administration of a single dose of 25 mg/kg of [3- ¹⁴ C]Anitrazafen shows the drug to be well absorbed from the gastro-intestinal tract and biliary excretion to be the major route of elimination of drug and/or metabolites. Plasma concentrations of total ¹⁴ C after subcutaneous administration of [3- ¹⁴ C]Anitrazafen in corn oil solution are about one half those found after oral administration.