623-58-5
中文名稱
3-氧代丁酸鈉鹽
英文名稱
ACETYLACETICACID,SODIUMSALT
CAS
623-58-5
分子式
C4H6O3
MOL 文件
623-58-5.mol
更新日期
2024/11/15 09:27:10
623-58-5 結(jié)構(gòu)式
基本信息
中文別名
乙酰乙酸鈉3-氧代丁酸鈉鹽
英文別名
Arbidol Impurity 45Sodium 3-oxobutanoate
sodium 2-acetoxyacetate
ACETYLACETICACID,SODIUMSALT
Acetoacetic acid sodium salt
3-Oxobutyric acid sodium salt
3-Oxobutanoic acid sodium salt
Sodium Acetoacetate DISCONTINUED. Please see L469065.
所屬類別
有機(jī)原料：羧酸類化合物及衍生物物理化學(xué)性質(zhì)
沸點(diǎn)52 °C(Press: 5 Torr)
儲(chǔ)存條件Store at -20°C,unstable in solution, ready to use.
形態(tài)Solid
顏色White to off-white
水溶解性Water: 50 mg/mL (403.00 mM)
常見問題列表
生物活性
Acetoacetic acid sodium salt 是一種非酯化脂肪酸代謝物，參與人類糖尿病的發(fā)展。Acetoacetic acid sodium salt 誘導(dǎo)氧化應(yīng)激，抑制牛肝細(xì)胞中極低密度脂蛋白的組裝。體外研究
Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes.
Acetoacetic acid (0.6, 2.4, 4.8 mM) increases malondialdehyde (MDA) content in high-dose group (GH) group, decreases mRNA expression of Mn SOD, Cu/Zn SOD, and glutathione peroxidase (GSH-Px) in all groups, lowers catalase (CAT) mRNA expression in medial-dose group (GM), and GH groups. In addition, Acetoacetic acid down-regulates the mRNA expression of apolipoprotein B100 (ApoB100), apolipoprotein E (ApoE), and low density lipoprotein receptor (LDLR). Thus, VLDL assembly is decreased andtriglyceride (TG) accumulation is increased in these bovine hepatocytes.