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6211-32-1

中文名稱 育亨賓堿
英文名稱 Rauwolscine hydrochloride
CAS 6211-32-1
分子式 C21H27ClN2O3
分子量 390.9
MOL 文件 6211-32-1.mol
更新日期 2023/03/20 15:41:21
6211-32-1 結構式 6211-32-1 結構式

基本信息

中文別名
蘿芙素
育亨賓堿
洛芙素鹽酸鹽
蘿芙素鹽酸鹽
ALPHA-鹽酸育亨賓
育亨賓提取物 育亨賓堿
蘿芙素鹽酸鹽(甄準不供應)
育亨賓鹽酸鹽, 來源于育亨賓
英文別名
Nsc407307
RAUWOLSCINE
ISOYOHIMBINE
MESOYOHIMBINE
RAUWOLSCINE HCL
ALPHA-YOHIMBINE
ALPHA-YOHIMBINE HCL
YOHIMBINE HCL, ALPHA-
RAUWOLSCINE HYDROCHLORIDE
Isoyohimbine hydrochloride
所屬類別
生物化工:提取物

物理化學性質(zhì)

熔點270-280°C
儲存條件Store at RT
溶解度H2O: soluble
形態(tài)solid
顏色white
敏感性感光

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS06
警示詞警告
危險性描述H300-H310-H330
危險品標志T
危險類別碼23/24/25
安全說明22-36/37/39-45
危險品運輸編號UN 1544 6.1/PG 2
WGK Germany3
RTECS號ZG1035000
危險等級6.1
海關編碼29339900

常見問題列表

生物活性
Rauwolscine hydrochloride是高效,選擇性的 α2 adrenergic 受體拮抗劑,Ki 值為12 nM。
靶點
TargetValue
α2 adrenergic receptor
()
12 nM(Ki)
體外研究

[ 3 H]Rauwolscine binding to α2 adrenergic receptor is reversible, stcreospccific, and saturable. [ 3 H]Rauwolscine specifically labels both the high and low affinity states of the α2 adrenergic receptor in brain membranes. [ 3 H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors. When using [ 3 H]5-HT as a radioligand, rauwolscine is determined to have relatively high affinity for the human receptor (K i human=14.3 nM, K i rat=35.8 nM). Saturation studies shows that the affinity of [ 3 H]Rauwolscine is similar in mouse, rat, rabbit, dog (2.33-3.03 nM) except man where it is significantly higher (0.98 nM) .

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