61890-25-3
中文名稱(chēng)
1-苯基-2-(吡啶-2-基)乙胺
英文名稱(chēng)
1-phenyl-2-(pyridin-2-yl)ethanamine
CAS
61890-25-3
分子式
C13H14N2
分子量
198.26
MOL 文件
61890-25-3.mol
61890-25-3 結(jié)構(gòu)式
基本信息
中文別名
(RAC)-拉尼西明1-苯基-2-(吡啶-2-基)乙胺
1-苯基-2-(吡啶-2-基)乙烷-1-胺
英文別名
(Rac)-Laniceminerac-Lanicemine 2HCl
1-Phenyl-2-(2-pyridinyl)ethanamine
1-phenyl-2-(pyridin-2-yl)ethanamine
物理化學(xué)性質(zhì)
沸點(diǎn)160 °C(Press: 2 Torr)
密度1.097±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 100 mg/mL (504.39 mM)
酸度系數(shù)(pKa)8.29±0.10(Predicted)
形態(tài)Liquid
顏色Colorless to light yellow
常見(jiàn)問(wèn)題列表
生物活性
(Rac)-Lanicemine ((Rac)-AZD6765) 是 Lanicemine 的外消旋體。Lanicemine (AZD6765) 是一種低捕獲的 NMDA 受體拮抗劑，Ki 為 0.56-2.1?μM。CHO 和爪蟾卵母細(xì)胞中，IC50 分別為 4-7 μM 和 6.4 μM。具有抗抑郁作用。靶點(diǎn)
NMDA receptor
體內(nèi)研究
Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Lanicemine (3, 10 or 30?mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 3, 10 or 30?mg/kg |
| Administration: | Intraperitoneal |
| Result: | Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity. |