607737-87-1
中文名稱
A 77-01
英文名稱
4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
CAS
607737-87-1
分子式
C18H14N4
分子量
286.33
MOL 文件
607737-87-1.mol
更新日期
2024/08/19 16:58:28
607737-87-1 結(jié)構(gòu)式
基本信息
中文別名
TGF-Β I型受體家族ALK5抑制劑(A 77-01)4-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]喹啉
英文別名
A77-01A-77-01
A 77-01
CS-1775
A7701
A 7701
A-7701
4-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline
4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
Quinoline, 4-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
4-[5-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]quinoline
4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline A 77-01
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度insoluble in H2O; ≥14.3 mg/mL in DMSO; ≥8.84 mg/mL in EtOH with gentle warming and ultrasonic
形態(tài)固體
顏色Off-white to light yellow
A 77-01價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-78349 | A 77-01 A 77-01 | 607737-87-1 | 5mg | 988元 |
| 2024/11/08 | HY-78349 | A 77-01 A 77-01 | 607737-87-1 | 10mM * 1mLin DMSO | 1086元 |
| 2024/11/08 | HY-78349 | A 77-01 A 77-01 | 607737-87-1 | 10mg | 1499元 |
常見問題列表
生物活性
A 77-01 是一種有效的 TGF-β I 型受體家族 ALK5 抑制劑，IC50 值為 25 nM。靶點
IC50: 25 nM (ALK5)
體外研究
A-77-01 (0.01-10 μM; 25 hours; Mv1Lu cells) treatment effectively inhibits TGF-β-induced transcriptional activation in concentration-dependent fashion.
A-77-01 (1 μM; 24-72 hours; Mv1Lu cells) treatment efficiently prevents the growth-inhibitory effects of TGF-β.
A-77-01 (1 μM; 30 minutes; HaCaT cells) treatment inhibits TGF-β-induced phosphorylation of Smad2.
RT-PCR
| Cell Line: | Mv1Lu cells |
| Concentration: | 0.01 μM, 0.03 μM, 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM |
| Incubation Time: | 25 hours |
| Result: | Inhibited the luciferase activity induced by TGF-β in concentration-dependent fashion. |
Cell Viability Assay
| Cell Line: | Mv1Lu cells |
| Concentration: | 1 μM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | Efficiently prevented the growth-inhibitory effects of TGF-β. |
Western Blot Analysis
| Cell Line: | HaCaT cells |
| Concentration: | 1 μM |
| Incubation Time: | 30 minutes |
| Result: | Inhibited TGF-β-induced phosphorylation of Smad2. |