6061-96-7
6061-96-7 結(jié)構(gòu)式
基本信息
(±)-2-甲基檸檬酸[干冰運(yùn)輸]
2-METHYLCITRIC ACID
DL-2-METHYLCITRIC ACID
YNOXCRMFGMSKIJ-UHFFFAOYSA-N
2-Methylcitric Acid (unlabelled)
2-hydroxybutane-1,2,3-tricarboxylic acid
1,2,3-Butanetricarboxylic acid, 2-hydroxy-
2-Hydroxy-3-methyl-1,2,3-propanetricarboxylic acid
2-Methylcitric Acid (mixture of diastereomers) (unlabelled)
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/05 | HY-113371 | 2-甲基檸檬酸 2-Methylcitric acid | 6061-96-7 | 5mg | 1400元 |
| 2025/02/05 | HY-113371 | 2-甲基檸檬酸 2-Methylcitric acid | 6061-96-7 | 10mg | 2400元 |
| 2025/02/05 | HY-113371 | 2-甲基檸檬酸 2-Methylcitric acid | 6061-96-7 | 25 mg | 4800元 |
常見問題列表
|
Human Endogenous Metabolite
|
2-Methylcitric acid (Methylcitric acid) impairs glutamate metabolism and induces permeability transition in brain mitochondria. 2-Methylcitric acid inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid (1-3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca
2+
-loaded mitochondria supported by different substrates.
2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid does not significantly impair glutamate mitochondrial transport in liver mitochondria.