59086-90-7
中文名稱
巨大戟醇-3,20-二苯甲酸酯
英文名稱
INGENOL 3,20-DIBENZOATE
CAS
59086-90-7
分子式
C34H36O7
分子量
556.65
MOL 文件
59086-90-7.mol
59086-90-7 結(jié)構(gòu)式
基本信息
中文別名
巨大戟醇-3,20-二苯甲酸酯 英文別名
ingenoldibenzoateINGENOL 3,20-DIBENZOATE
1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one, 6-(benzoyloxy)-4-[(benzoyloxy)methyl]-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-1,1,7,9-tetramethyl-, (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-
常見問題列表
生物活性
Ingenol 3,20-dibenzoate 是一種有效的蛋白激酶C (PKC) 亞型選擇性激動劑。Ingenol 3,20-dibenzoate 誘導(dǎo) nPKC-delta、-epsilon 和 -theta 和 PKC-mu 從胞質(zhì)部分選擇性轉(zhuǎn)移到顆粒組分，并通過從頭合成大分子誘導(dǎo)形態(tài)上典型的凋亡 (apoptosis)。Ingenol 3,20-dibenzoate 可促進(jìn) NK 細(xì)胞產(chǎn)生 IFN-γ 和脫顆粒，尤其是當(dāng) NSCLC 細(xì)胞刺激 NK 細(xì)胞時。體外研究
Ingenol 3,20-dibenzoate (0-10000 nM; 4 hours) enhanced NK cells (stimulated by A549 cells and H1299 cells) degranulation.
Ingenol 3,20-dibenzoate (0.001-10 μg/ml) dose dependently promoted UT-7/EPO cell proliferation with an EC50 of 0.27 μg/ml (485 nM).
體內(nèi)研究
Ingenol 3,20-dibenzoate (20 μg/mouse; i.p.; on days 3, 7, and 11) lessens the anemia induced by 5-fluorouracil in an in vivo mouse model.
| Animal Model: | Male C57BL/6 mice (8–12 weeks old) |
| Dosage: | 20 μg/mouse |
| Administration: | I.p.; On days 3, 7, and 11 |
| Result: | Severity of 5-FU–induced anemia was lessened by IDB treatment on days 12 and 20. |