582323-16-8
中文名稱
ICA 069673
英文名稱
ICA 069673
CAS
582323-16-8
分子式
C11H6ClF2N3O
分子量
269.63
MOL 文件
582323-16-8.mol
更新日期
2023/03/20 15:41:27
582323-16-8 結(jié)構(gòu)式
基本信息
中文別名
化合物ICA069673 英文別名
ICA 069673ICA069673
ICA-069673
ICA-069673 >=98% (HPLC)
N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-
物理化學(xué)性質(zhì)
沸點(diǎn)358.9±37.0 °C(Predicted)
密度1.539±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,Room Temperature
溶解度DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM)
DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM)
Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM)
DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM)
Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM)
酸度系數(shù)(pKa)9.47±0.70(Predicted)
形態(tài)粉末
顏色White to off-white
常見問題列表
生物活性
ICA 069673 (compound 51) 是一種口服活性、有效的 KCNQ2/Q3 potassium channel 的選擇性激活劑，其對(duì)KCNQ2/Q3和KCNQ3/Q5的EC50值分別為0.69 μM和14.3 μM。靶點(diǎn)
| Target | Value |
|
KCNQ2/Q3
(Cell-free assay) | 0.69 μM(EC50) |
|
KCNQ3/Q5
(Cell-free assay) | 14.3 μM(EC50) |
體外研究
ICA-069673 is found to be 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5 and has no measurable activity against a panel of cardiac ion channels (IC 50 values > 30 μM for hERG, Nav1.5, L type channels, and KCNQ1) as well as no activity on GABA(A) gated channels at 10 μM. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, an 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3. Based on ICA73 sensitivity of chimeric constructs of the transmembrane segments of KCNQ2 and KCNQ3, this drug appears to interact with the KCNQ2 voltage sensor (S1-S4).