570390-00-0
中文名稱
A2TI-1
英文名稱
Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-
CAS
570390-00-0
分子式
C20H22N4O2S
分子量
382.48
MOL 文件
570390-00-0.mol
更新日期
2023/03/20 15:41:25
570390-00-0 結(jié)構(gòu)式
基本信息
英文別名
A2ti-1Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-
物理化學(xué)性質(zhì)
沸點(diǎn)642.4±65.0 °C(Predicted)
密度1.26±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 250 mg/mL (653.63 mM)
酸度系數(shù)(pKa)15.06±0.40(Predicted)
形態(tài)Solid
顏色White to off-white
A2TI-1價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-136465 | A2ti-1 | 570390-00-0 | 5mg | 2333元 |
| 2024/11/08 | HY-136465 | A2ti-1 | 570390-00-0 | 10mM * 1mLin DMSO | 2566元 |
| 2024/11/08 | HY-136465 | A2ti-1 | 570390-00-0 | 10mg | 3500元 |
常見(jiàn)問(wèn)題列表
生物活性
A2ti-1 是選擇性的，高親和力的膜聯(lián)蛋白 A2/S100A10 異四聚體 (A2t) 抑制劑，IC50 為 24 μM。A2ti-1 特異性破壞 A2 和 S100A10 之間的蛋白質(zhì)相互作用。A2ti-1 可防止人乳頭瘤病毒 16 型 (HPV16) 感染。靶點(diǎn)
IC50: 24 μM (A2t)
體外研究
A2ti-1 (compound 1 b) is an annexin A2-S100A10 protein-protein interaction blocker.
A2ti-1 (100 μM; for 72 hours) reduces HPV16 PsV infection of HeLa cells in a dose-dependent manner.
A2ti-1 (10, 25, 50, 75, 100 μM; 24 hours) significantly reduces CFDA-SE-labelled HPV16 PsV entry into HeLa cells in a dose-dependent manner.
Cell Viability Assay
| Cell Line: | HeLa cells |
| Concentration: | 100 μM |
| Incubation Time: | For 72 hours |
| Result: | Reduced HPV16 PsV infection of HeLa cells in a dose-dependent manner with 100% inhibition of infection observed at 100 μM and similar results were observed in HaCaT cells. |