56563-17-8
中文名稱
PLURISIN #2
英文名稱
1(2H)-Pyrimidinecarboxamide, 5-fluoro-3,4-dihydro-2,4-dioxo-N-phenyl-
CAS
56563-17-8
分子式
C11H8FN3O3
分子量
249.2
MOL 文件
56563-17-8.mol
更新日期
2023/03/20 15:41:25
56563-17-8 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
熔點(diǎn)223 °C
密度1.51±0.1 g/cm3(Predicted)
儲(chǔ)存條件4°C, protect from light, stored under nitrogen
溶解度DMSO: 5 mg/mL (20.06 mM)
酸度系數(shù)(pKa)6.88±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
PluriSIn #2 是一種拓?fù)洚悩?gòu)酶 II α (TOP2A) 的選擇性轉(zhuǎn)錄抑制劑。PluriSIn #2 是一種選擇性消除未分化的人類多能干細(xì)胞 (hPSC) 的化合物。靶點(diǎn)
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topoisomerase II alpha
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體外研究
PluriSIn #2 (20 μM; 12 hours) treatment reduces TOP2A expression at the protein level.
A 24h exposure of PluriSIn #2 (20 μM) is sufficient to induce massive cell death in hPSCs, but doesn’t affect the viability of various other cell types derived from them.
Western Blot Analysis
| Cell Line: | B153 and HUES9 human pluripotent stem cells (hPSCs) |
| Concentration: | 20 μM |
| Incubation Time: | 12 hours |
| Result: | Reduced TOP2A expression at the protein level. |