55266-18-7
中文名稱
內消旋-四(4 - 羧基苯基)卟啉氯化錳(Ⅲ)
英文名稱
Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride
CAS
55266-18-7
分子式
C48H28ClMnN4O8
分子量
879.149
MOL 文件
55266-18-7.mol
55266-18-7 結構式
基本信息
中文別名
四(4-羧基苯基)卟啉氯化錳(Ⅲ)內消旋-四(4 - 羧基苯基)卟啉氯化錳(Ⅲ)
英文別名
Mn(III)TBAP (chloride)Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride
Manganese(III) meso-tetra(4-carboxyphenyl)porphine chloride
5,10,15,20-Tetrakis(4-carboxyphenyl)porphyrin-Mn(III) chloride (MnTBAP)
常見問題列表
簡介
MnTBAP (55266-18-7) 是一種超氧化物歧化酶 (SOD) 模擬物，可用作過氧亞硝酸鹽清除劑，但不清除一氧化氮。生物活性
MnTBAP chloride 是一種超氧化物歧化酶 (SOD) 模擬物和過氧亞硝酸鹽清除劑。MnTBAP chloride 是一種錳卟啉配合物，具有抗氧化性能。MnTBAP chloride 通過上調 BMPR-II 和抑制 NFκB 信號傳導介導抗炎作用。MnTBAP chloride 具有抗氧化性能，具有用于研究慢性腎臟疾病 (CKDs) 纖維化反應的潛力。靶點
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NFκB
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體外研究
MnTBAP chloride (pretreated 1.14?μM before TGF-β1 of 10?ng/mL) partially but significantly restores E-cadherin reduction and suppresses the induction of α-SMA and vimentin in immortalized mouse proximal tubular cells (mPTCs).
MnTBAP chloride (50 μM; 6 hours) increases BMPR-II mRNA by 1.3-fold at 2 h, but does not affect protein expression of BMPR-II during a time course of 16 h in HUVECs. MnTBAP chloride increases phosphorylation of Smad 1/5, suggesting modulation of the BMP signaling pathway.
體內研究
MnTBAP chloride (10?mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice.
| Animal Model: | C57BL/6J mice with 5/6 nephrectomy (Nx) |
| Dosage: | 10?mg/kg |
| Administration: | IP; three times per week for twelve weeks |
| Result: | Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys. |