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53783-83-8

中文名稱 TROMANTADINE
英文名稱 tromantadine
CAS 53783-83-8
分子式 C16H28N2O2
分子量 280.41
MOL 文件 53783-83-8.mol
53783-83-8 結(jié)構(gòu)式 53783-83-8 結(jié)構(gòu)式

基本信息

中文別名
化合物 T13209
英文別名
N-(1-Adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide
Acetamide, 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-yl-

物理化學(xué)性質(zhì)

沸點(diǎn)434.5±28.0 °C(Predicted)
密度1.09±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)14.58±0.20(Predicted)
形態(tài)Oil
顏色Colorless to light yellow

常見(jiàn)問(wèn)題列表

簡(jiǎn)介
Tromantadine 是一種用于治療單純皰疹病毒的抗病毒藥物。 其商品名 Viru-Merz 和 Viru-Merz Serol,以凝膠形式提供。其性能與阿昔洛韋相似。
生物活性
Tromantadine,Amantadine 衍生物,具有抗皰疹活性,可抑制單純皰疹病毒1型 (HSV-1) 和 HSV-2 的復(fù)制。
靶點(diǎn)

HSV-1

HSV-2

體外研究

Tromantadine inhibits herpes simplex virus type 1 (KOS strain)-induced cytopathic effect and virus replication with limited toxicity to the cells. Vero and HEp-2 cells tolerate up to 2 mg of Tromantadine per 2x10 6 cells for 24-, 48-, or 96-h incubation periods with little change in cell morphology. Treatment of the cells with 10 to 50 μg of Tromantadine reduces herpes simplex virus-induced cytopathic effect. Treatment with 100 to 500 μg of Tromantadine inhibits herpes simplex virus-induced cytopathic effect and reduces virus production. Complete inhibition of virus production is observed with treatments of 500 μg to 1 mg. The antiherpetic activity of Tromantadine is dependent upon the viral inoculum size and the time of addition of the compound with respect to infection. Virion synthesis and viral polypeptide synthesis are inhibited by addition of Tromantadine at the time of infection or 4 h postinfection. Tromantadine raises the bilayer to hexagonal phase transition temperature of synthetic phosphatidylethanolamines and is less disruptive to phospholipid packing. Tromantadine acts similar to cyclosporin A, previously demonstrated to inhibit viral-induced cell-cell fusion.

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