52328-97-9
52328-97-9 結(jié)構(gòu)式
基本信息
中文別名
(1E,6E)-1,7-雙(3,4-二甲氧基苯基)-4,4-二甲基庚-1,6-二烯-3,5-二酮 英文別名
FLLL31FLLL31 >=98% (HPLC)
Tetramethylcurcumin
FLLL31
FLLL-31
FLLL 31
(E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione
(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethyl-, (1E,6E)-
所屬類別
生物化工：植物提取物物理化學(xué)性質(zhì)
沸點594.5±50.0 °C(Predicted)
密度1.140±0.06 g/cm3(Predicted)
儲存條件2-8°C
溶解度二甲基亞砜：≥10mg/mL
形態(tài)粉末
顏色黃色
常見問題列表
生物活性
Tetramethylcurcumin (FLLL31) 是來自于姜黃素，通過選擇性結(jié)合 Janus 激酶 2 和 STAT3 Src 同源性 2 結(jié)構(gòu)域來特異性抑制 STAT3 的磷酸化。Tetramethylcurcumin 具有抗炎和抗癌作用。靶點
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STAT3
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體外研究
Tetramethylcurcumin (FLLL31; 2.5 and 5 μM;?for 24 hours) downregulats STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells.
Tetramethylcurcumin inhibits cell viability, cell invasion. Tetramethylcurcumin is a effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines.