52238-35-4
52238-35-4 結構式
常見問題列表
生物活性
9-Hydroxyellipticine hydrochloride 是 Topo II 和RyR 的抑制劑。9-Hydroxyellipticine hydrochloride 具有抗腫瘤、抗氧化和釋放兒茶酚胺的活性。 9-Hydroxyellipticine hydrochloride 對 Hela S-3 和293T 細胞的IC50 值分別為1.6 μM 和1.2μM。靶點
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Topoisomerase II
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體外研究
9-Hydroxyellipticine (9HE) causes selective inhibition of p53 protein phospborylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 μM.
體內研究
9-Hydroxyellipticine (5 or 10 mg/kg, ip) results in chromosome clumping and sister chromatid exchange in murine bone marrow cells.
| Animal Model: | Three- to five-month-old C57B1/6 male mice. |
| Dosage: | 5 or 10 mg/kg. |
| Administration: | IP. |
| Result: | Resulted in chromosome clumping, chromatid aberrations, and micronuclei formation in murine bone marrow cells. |