50932-19-9
中文名稱
梓醇 6-咖啡酸酯
英文名稱
[(1aS)-6α-[[(E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1a,1bα,2,5aα,6,6aβ-hexahydro-1a-hydroxymethyloxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside
CAS
50932-19-9
分子式
C24H28O13
分子量
524.48
MOL 文件
50932-19-9.mol
50932-19-9 結(jié)構(gòu)式
基本信息
中文別名
梓醇 6-咖啡酸酯 英文別名
VermisideVerminoside
Caffeoyl catalpol
Catalpol 6-caffeate
[(1aS)-6α-[[(E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1a,1bα,2,5aα,6,6aβ-hexahydro-1a-hydroxymethyloxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside
β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-6-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl
所屬類別
天然產(chǎn)物：環(huán)烯醚萜衍生物物理化學(xué)性質(zhì)
沸點820.3±65.0 °C(Predicted)
密度1.69±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)9.31±0.10(Predicted)
常見問題列表
生物活性
Verminoside 是從 Kigelia africana 分離出的一種環(huán)烯醚萜，具有抗炎和顯著的抗氧化活性，其自由基清除活性為 2.5 μg/mL。Verminoside 對人淋巴細胞的遺傳毒性與 PARP-1 和 p53 蛋白水平升高有關(guān)。靶點
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PARP-1
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體外研究
Verminoside (Compound 1; 0.01-1 mM; 25 hours; J774.A1 macrophages) treatment shows significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages.
Western Blot Analysis
| Cell Line: | J774.A1 macrophages |
| Concentration: | 0.01 mM, 0.1 mM or 1 mM |
| Incubation Time: | 25 hours |
| Result: | Showed significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages. |