509102-00-5
中文名稱
4-[[[2-(環(huán)己基亞氨基)-4-甲基-3(2H)-噻唑基]亞氨基]甲基]-1,2,3-苯三醇
英文名稱
1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-
CAS
509102-00-5
分子式
C17H21N3O3S
分子量
347.43
MOL 文件
509102-00-5.mol
509102-00-5 結(jié)構(gòu)式
基本信息
中文別名
MCL-1抑制劑(MIM1)4-[[[2-(環(huán)己基亞氨基)-4-甲基-3(2H)-噻唑基]亞氨基]甲基]-1,2,3-苯三醇
英文別名
MIM1CS-1192
MIM 1
MIM-1
Inhibitor of Mcl-1
1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-
4-[[[2-(Cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-1,2,3-benzenetriol
1,2,3-Benzenetriol, 4-[[[2-(cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)559.6±60.0 °C(Predicted)
密度1.40±0.1 g/cm3(Predicted)
溶解度insoluble in EtOH; insoluble in H2O; ≥12.15 mg/mL in DMSO
酸度系數(shù)(pKa)7.73±0.45(Predicted)
形態(tài)A crystalline solid
顏色White to off-white
常見問題列表
生物活性
MIM-1 是一種骨髓細(xì)胞因子 1 (Mcl-1) 抑制劑。靶點(diǎn)
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Mcl-1
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體外研究
MIM-1 selectively targets the BH3 binding groove of Mcl-1, with Bak-dependent apoptotic activity. To estimate the sensitivity of HA and T98G cells to the apoptosis inhibitor MIM-1, the colorimetric MTT assay is used to detect cell viability and to determine the IC 50 value. The IC 50 value of the HA cell line is almost 5-fold lower (16.10 μM) compared with the IC 50 of the T98G cell line (80.20 μM) after MIM-1 inhibitor treatment.