50-42-0
50-42-0 結(jié)構(gòu)式
基本信息
鹽酸阿地芬尼
鹽酸阿地芬寧
鹽酸阿的芬寧
解痙素
鹽酸二苯胺乙酯
鹽酸屈生丁
阿地芬寧
ADIPHENINE
ADIPHENINE HCL
ADIPHENINE HYDROCHLORIDE
ALPHA-PHENYLBENZENEACETIC ACID 2-[DIETHYLAMINO]ETHYL ESTER HYDROCHLORIDE
DIPHENYLACETIC ACID 2-(DIETHYLAMINO)ETHYL ESTER HYDROCHLORIDE
DIPHENYLACETYLDIETHYLAMINOETHANOL HYDROCHLORIDE
aceticacid,diphenyl-,2-(diethylamino)ethylester,hydrochloride
adifeninhydrochloride
adiphenhydrochloride
benzeneaceticacid,alpha-phenyl-,2-(diethylamino)ethyl-ester,hydrochloride
difacilhydrochloride
diphacilhydrochloride
diphenylacetatedudiethylamino-ethanolchlorhydrate
ethanol,2-(diethylamino)-,2,2-diphenylacetate,hydrochloride
patrovina
paxil(anticolinergic)
sentiv
spasmolytinhydrochloride
trasentinehydrochloride
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
| Target | Value |
|
α3β4 nAChR
(Cell-free assay) | 1.8 μM |
|
α1 nAChR
(Cell-free assay) | 1.9 μM |
|
α4β2 nAChR
(Cell-free assay) | 3.7 μM |
|
α4β4 nAChR
(Cell-free assay) | 6.3 μM |
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α1*-nAChR in a dose-dependent manner in TE671/RD cells, with an IC
50
of 1.9 μM.
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α3α4*-nAChR in a dose-dependent manner in SH-SY5Y cells, with an IC
50
of 1.8 μM.
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α4β2- and α4β4-nAChR in a dose-dependent manner in SH-EP1 cells, with IC
50
s of 3.7 and 6.3 μM, respectively.
Adiphenine (50-200 μM; 30-60 s) decreases the frequency of ACh-induced single-channel currents in HEK 293 cells.
Adiphenine (i.p.) prevents the hindleg tonic-extensor component of maximal electroshock seizures (MES), with an ED 50 of 62 mg/kg in mice.