491871-58-0
中文名稱
TCS PIM-1 1
英文名稱
3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
CAS
491871-58-0
分子式
C18H11BrN2O2
分子量
367.2
MOL 文件
491871-58-0.mol
更新日期
2024/11/05 13:11:14
491871-58-0 結(jié)構(gòu)式
基本信息
中文別名
PIM-1激酶抑制劑(TCS PIM-1 1)3-氰基-4-苯基-6-(3-溴-6-羥基苯基)-2(1H)-吡啶酮
6-(5-溴-2-羥基苯)-2-氧代-4-苯基-1,2-二氫吡啶-3-腈
英文別名
CS-1482TCS PIM-1
SC 204330
TCS PIM-1 1
TCS PIM-1 1, >=98%
TCS PIM-1 1(sc-204330)
SC 204330
TCS PIM 1-1
3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
6-(5-Bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarbonitrile
3-Pyridinecarbonitrile, 6-(5-bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
沸點592.6±50.0 °C(Predicted)
密度1.63±0.1 g/cm3(Predicted)
儲存條件Store at +4°C
溶解度insoluble in H2O; insoluble in EtOH; ≥12.8 mg/mL in DMSO
酸度系數(shù)(pKa)6.93±0.10(Predicted)
形態(tài)固體
顏色Light yellow to yellow
常見問題列表
生物活性
TCS PIM-1 1 (SC 204330)是一種有效的、選擇性的 ATP-competitive Pim-1 kianse 抑制劑，其IC50值為50 nM，對 Pim-2 和 MEK1/MEK2 具有良好的選擇性（IC50> 20000 nM）。靶點
| Target | Value |
|
Pim1
(Cell-free assay) | 50 nM |
體外研究
TCS PIM-1 1 (compound 1), a substituted pyridone scaffold, binds convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggests that TCS PIM-1 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2. Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors. TCS PIM-1 1 serves both as a starting point for SAR chemical syntheses and was used for co-crystallization with Pim-1 protein.