475221-20-6
中文名稱
NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40
英文名稱
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
CAS
475221-20-6
分子式
C206H324N56O65
分子量
4625.11
MOL 文件
475221-20-6.mol
更新日期
2024/12/31 13:25:38
475221-20-6 結(jié)構(gòu)式
基本信息
中文別名
抑制劑多肽NOGO-66 (1-40)AC-ARG-ILE-TYR-LYS-GLY-VAL-ILE-GLN-ALA-ILE-GLN-LYS-SER-ASP-GLU-GLY-HIS-PRO-PHE-ARG-ALA-TYR-LEU-GLU-SER-GLU-VAL-ALA-ILE-SER-GLU-GLU-LEU-VAL-GLN-LYS-TYR-SER-ASN-SER-NH2
英文別名
NEP1-40NOGO-66 (1-40)
PubChem ID: 90488731
Nogo Extracellular Peptide
M.W. 4625.11 C206H324N56O65
NOGO EXTRACELLULAR PEPTIDE, 1-40
NOGO-66 (1-40) ANTAGONIST PEPTIDE
NEP1-40
NOGO EXTRACELLULAR PEPTIDE
1-40
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
ARG-ILE-TYR-LYS-GLY-VAL-ILE-GLN-ALA-ILE-GLN-LYS-SER-ASP-GLU-GLY-HIS-PRO-PHE-ARG-ALA-TYR-LEU-GLU-SER-GLU-VAL-ALA-ILE-SER-GLU-GLU-LEU-VAL-GLN-LYS-TYR-SER-ASN-SER-NH2
物理化學(xué)性質(zhì)
儲存條件-20°C
溶解度H2O: 1 mg/mL
溶解度H2O：1 mg/mL
形態(tài)solid
顏色white
水溶解性Soluble to 1 mg/ml in water
NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-P1242 | NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40 NEP(1-40) | 475221-20-6 | 1 mg | 4000元 |
| 2022/09/18 | HY-P1242 | NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40 NEP(1-40) | 475221-20-6 | 5 mg | 13500元 |
| 2022/09/18 | HY-P1242 | NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40 NEP(1-40) | 475221-20-6 | 10 mg | 21500元 |
常見問題列表
生物活性
NEP(1-40) 是 Nogo-66 受體 (NgR) 的肽類拮抗劑，通過限制髓蛋白抑制逆轉(zhuǎn)損傷引起的小膠質(zhì)細(xì)胞形態(tài)分布的改變。體內(nèi)研究
NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies.
| Animal Model: | 74 male Sprague-Dawley rats (328-377 g). |
| Dosage: | 89 μg/kg (97.5% PBS and 2.5% DMSO). |
| Administration: | IP, 15 min and 19 h post-injury. |
| Result: |
Reduced NgR function immediately post-injury.
Increased number of amoeboid microglia/macrophages at 2 days post-injury |