461054-93-3
中文名稱
(3S,6S,12aS)-1,2,3,4,6,7,12,12a-八氫-9-甲氧基-6-(2-甲基丙基)-1,4-二氧代吡嗪并[1',2':1,6]吡啶并[3,4-b]吲哚-3-丙酸叔丁酯
英文名稱
(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester
CAS
461054-93-3
分子式
C26H35N3O5
分子量
469.57
MOL 文件
461054-93-3.mol
更新日期
2024/12/25 20:56:15
461054-93-3 結(jié)構(gòu)式
基本信息
中文別名
KO 143 水合物乳腺癌耐藥蛋白抑制劑(BCRP抑制劑)
1,6]吡啶并[3,4-B]吲哚-3-丙酸叔丁酯]
[(3S,6S,12AS)-1,2,3,4,6,7,12,12A-八氫-9-甲氧基-6-(2-甲基丙基)-1,4-二氧代吡嗪并[1',2'
(3S,6S,12AS)-八氫-9-甲氧基-6-(2-甲基丙基)-1,4-二氧吡嗪并[1',2':1,6]吡啶并[3,4-B]吲哚-3-羧酸叔丁酯
(3S,6S,12AS)-1,2,3,4,6,7,12,12A-八氫-9-甲氧基-6-(2-甲基丙基)-1,4-二氧代吡嗪并[1',2':1,6]吡啶并[3,4-B]吲哚-3-丙酸叔丁酯
英文別名
Ko 14312aS)-
4-dioxo-
6]pyrido[3
Ko143 ,99%
Pyrazino[1'
Ko143 hydrate
KO 143
KO-143
KO143
4-b]indole-3-propanoicacid
12a-octahydro-9-Methoxy-6-(2-Methylpropyl)-1
物理化學(xué)性質(zhì)
熔點(diǎn)147 ºC
沸點(diǎn)689.8±55.0 °C(Predicted)
密度1.24
儲(chǔ)存條件Desiccate at -20°C
溶解度二甲基亞砜：>10mg/mL
酸度系數(shù)(pKa)13.31±0.60(Predicted)
形態(tài)粉末
顏色白色至灰白色
穩(wěn)定性從購買之日起 2 年內(nèi)保持穩(wěn)定。防止暴露在潮濕環(huán)境中。 DMSO 或乙醇溶液可在 -20°C 下保存長(zhǎng)達(dá) 3 個(gè)月。
安全數(shù)據(jù)
常見問題列表
生物活性
KO143 是一種有效的、相對(duì)選擇性的 ATP-binding cassette sub-family G member 2 (ABCG2/BCRP) 抑制劑。KO143 可降低ABCG2的ATPase活性，對(duì)應(yīng)IC50值為9.7 nM。靶點(diǎn)
| Target | Value |
|
BCRP
(Cell-free assay) | 9.7 nM |
體外研究
Ko143 (10 nM) significantly decreases (2.5-fold) the IC 50 of MTX for HEK G2 cells and mouse G2 cells. Ko143 (1-100 μM) metabolite does not inhibit the function of ABC Transporters. Reversal of drug resistance in SKF 104864A-selected mouse MEF3.8/T6400 cells and human IGROV1/T8 cells by FTC analogue Ko143. Ko143 is applied at zero, one, or eight times the EC 90 concentration of 25 nM. Ko143 inhibits BCRP-mediated transport of ZD 4522 in Madin-Darby Canine Kidney (MDCK) 2-BCRP421CC (wild type) cells and MDCK2-BCRP421AA (mutant type) cells.
體內(nèi)研究
Ko143 (10 mg/kg, p.o.) increases the oral availability of SKF 104864A in mice. Ko143 significantly affects the pharmacokinetics of ZD 4522 in rats.