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4551-00-2

中文名稱(chēng) 9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
英文名稱(chēng) 9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
CAS 4551-00-2
分子式 C22H15NO2
分子量 325.36
MOL 文件 4551-00-2.mol
4551-00-2 結(jié)構(gòu)式 4551-00-2 結(jié)構(gòu)式

基本信息

中文別名
化合物 T12978
英文別名
NSC-70220
SOS1 inhibitor 1
9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-

物理化學(xué)性質(zhì)

熔點(diǎn)186 °C
沸點(diǎn)569.6±49.0 °C(Predicted)
密度1.321±0.06 g/cm3(Predicted)
儲(chǔ)存條件Store at -20°C,unstable in solution, ready to use.
溶解度DMSO: 12.5 mg/mL (38.42 mM)
形態(tài)Solid
顏色Light yellow to yellow
9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/11/08HY-1017969H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
NSC-70220
4551-00-25mg900元
2024/11/08HY-1017969H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
NSC-70220
4551-00-210mg1500元
2024/11/08HY-1017969H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]-
NSC-70220
4551-00-225mg3000元

常見(jiàn)問(wèn)題列表

生物活性
NSC-70220 是一種選擇性的變構(gòu) SOS1 抑制劑。NSC-70220 抑制變構(gòu)位點(diǎn)激活,并部分抑制催化位點(diǎn)激活。NSC-70220 具有抗癌作用。
靶點(diǎn)

SOS1.

體外研究

The growth inhibitory rate (IR)=(average OD value in the control group-average OD value in the treatment group)/average OD value in the control group×100% are compared. Treatments with NSC-70220 at 40 μM and NSC-658497 at 30 μM result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of NSC-70220 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of NSC-70220 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of NSC-70220 overnight resulted in lower expression levels of P-ERK.

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