42422-68-4
中文名稱(chēng)
B-赤霉醇
英文名稱(chēng)
BETA-ZEARALANOL
CAS
42422-68-4
分子式
C18H26O5
分子量
322.4
MOL 文件
42422-68-4.mol
更新日期
2024/12/24 08:42:51
42422-68-4 結(jié)構(gòu)式
基本信息
中文別名
B-赤霉醇Β-玉米赤霉醇
-ZEARALANOL
英文別名
P-1560taleranol
β-Zeranol
BETAZERANOL
B-zearalanol
β-Zearalanol
BETA-ZEARALANOL
Zearalanol, beta-
P-1560【pharmaceutical】
Taleranol (β-Zearalanol)
所屬類(lèi)別
分析化學(xué)：食品和化妝品標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
熔點(diǎn)134-137°C
沸點(diǎn)576.0±50.0 °C(Predicted)
密度1.153±0.06 g/cm3(Predicted)
閃點(diǎn)2℃
儲(chǔ)存條件2-8°C
溶解度Methanol: 10 mg/ml
酸度系數(shù)(pKa)8.08±0.60(Predicted)
形態(tài)固體
顏色White to off-white
BRN4844761
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H314-H361d
危險(xiǎn)品標(biāo)志T,Xn,F
危險(xiǎn)類(lèi)別碼60-36/37/38-36-20/21/22-11
安全說(shuō)明53-36/37/39-45-36/37-16
危險(xiǎn)品運(yùn)輸編號(hào)UN 1648 3 / PGII
WGK Germany3
常見(jiàn)問(wèn)題列表
生物活性
Beta-Zearalanol 是由鐮刀菌屬 Fusarium 產(chǎn)生的一種霉菌毒素，可以在哺乳動(dòng)物生殖細(xì)胞中引起細(xì)胞凋亡 (apoptosis) 和氧化應(yīng)激反應(yīng)。 Beta-Zearalanol 是玉米赤霉烯酮（ZEA）的衍生物，可以與葡萄糖醛酸 (glucuronic acid) 結(jié)合。體外研究
βeta-Zearalenol (0-200 μM; 24 hours) inhibits BGC proliferation in a dose-dependent manner, with an IC 50 of 25 μM. βeta-Zearalenol (0-100 μM; 72 hours) shows high toxic with an IC 50 of 15.2 μM in the HepG2 cells, synergistic effect of β-ZOL+ZEN or β-ZOL+α-ZOL with IC 50 values of 19.8 uM, 16.8 uM, respectively. βeta-Zearalenol (0-10 μM; 72 hours) has the highest inhibition effect on the all three investigated cytokines: IL-8, IL-1β and TNF-α by comparation with ZEA or α-Zearalenol.
Cell Viability Assay
| Cell Line: | HepG2 cells |
| Concentration: | 0-100 μM |
| Incubation Time: | 72 hours |
| Result: | Shown a dose-dependent reduction of viability of cells treated with Beta-Zearalanol. |
Cell Proliferation Assay
| Cell Line: | BGC cells |
| Concentration: | 0 μM, 5 μM, 10 μM, 15 μM, 25 μM, 50 μM, 100 μM, and 200 μM |
| Incubation Time: | 24?hours |
| Result: | Inhibited cell proliferation in a dose-dependent manner. |
RT-PCR
| Cell Line: | HepG2 cells |
| Concentration: | 1 μM, 5 μM, 10 μM |
| Incubation Time: | 72 hours |
| Result: | Had the higher cytotoxic effect in comparation with α-Zearalenol. |