41179-33-3
中文名稱
CMPD1
英文名稱
2'-FLUORO-N-(4-HYDROXYPHENYL)-[1,1'-BIPHENYL]-4-BUTANAMIDE
CAS
41179-33-3
分子式
C22H20FNO2
分子量
349.4
MOL 文件
41179-33-3.mol
41179-33-3 結(jié)構(gòu)式
基本信息
中文別名
化合物CMPD14-(2'-氟-[1,1'-聯(lián)苯]-4-基)-N-(4-羥基苯基)丁酰胺
英文別名
SRA1CMD1
CMPD-1
MK2a Inhibitor
CMPD-1 (CMPD 1
Steroid receptor RNA activator 1
ANTI-SOX9 antibody produced in mouse
MK2a Inhibitor - CAS 41179-33-3 - Calbiochem
ANTI-SRA1 (C-TERM) antibody produced in rabbit
Monoclonal Anti-SOX9 antibody produced in mouse
物理化學(xué)性質(zhì)
熔點(diǎn)128-130 °C
沸點(diǎn)585.0±50.0 °C(Predicted)
密度1.229±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度Soluble to 100 mM in DMSO and to 100 mM in ethanol
酸度系數(shù)(pKa)10.11±0.26(Predicted)
形態(tài)淡黃色固體
顏色Off-white to light brown
常見問題列表
生物活性
CMPD1 是一種選擇性且非 ATP 競爭性的 p38 MAPK 介導(dǎo)的 MK2 磷酸化抑制劑，表觀 Ki (Kiapp) 值為 330 nM。靶點(diǎn)
Ki app : 330?nM (MK2 phosphorylation)
體外研究
CMPD1 does not inhibit p38 MAPK-mediated phosphorylation of other two substrates, MBP and ATF2.
CMPD1 induced mitotic arrest and apoptosis in U87 cells.
CMPD1 inhibits tubulin polymerisation in glioblastoma cells.