402939-18-8
中文名稱
Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem
英文名稱
Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem
CAS
402939-18-8
分子式
C19H38N2O
分子量
310.52
MOL 文件
402939-18-8.mol
更新日期
2024/11/08 11:24:23
402939-18-8 結(jié)構(gòu)式
基本信息
中文別名
化合物1-CYCLOHEXYL-3-DODECYL UREA 英文別名
Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem物理化學性質(zhì)
沸點465.1±12.0 °C(Predicted)
密度0.92±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度Ethanol: 16.67 mg/mL (53.68 mM)
酸度系數(shù)(pKa)14.29±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | S0548 | Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem 1-Cyclohexyl-3-dodecyl urea | 402939-18-8 | 5mg | 670.48元 |
| 2024/11/08 | S0548 | Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem 1-Cyclohexyl-3-dodecyl urea | 402939-18-8 | 25mg | 3380.33元 |
常見問題列表
生物活性
1-Cyclohexyl-3-dodecyl urea (CDU, N-Cyclohexyl-N-dodecyl urea, NCND) 是一種高選擇性的 soluble epoxide hydrolase (sEH) 的抑制劑，可增加 epoxyeicosatrienoic acids (EETs) 的表達水平。靶點
| Target | Value |
|
sEH
() |
體內(nèi)研究
1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) (?intraperitoneal injection; 3mg/day; 4 days) lowers systolic blood pressure by 30 mm Hg in Ang II hypertensive animals, whereas the corn oil vehicle has no effect on blood pressure in normotensive or Ang II hypertensive animals.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 3mg/day |
| Administration: | Intraperitoneal injection; 4 days |
| Result: | Had antihypertensive properties. |