402934-09-2
402934-09-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 BBS-4 英文別名
BBS 42-PyrrolidinecarboxaMide, N-[2-(1,3-benzodioxol-5-yl)ethyl]-1-[2-(1H-iMidazol-1-yl)-6-Methyl-4-pyriMidinyl]-, (2R)-
物理化學(xué)性質(zhì)
密度1.43±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)14.54±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
BBS4 is a potent, orally active and selective inducible nitric oxide synthase dimerization inhibitor. BBS4 inhibits the dimerization of iNOS monomers, thus preventing the formation of the dimeric, active form of the enzyme. BBS4 significantly ameliorated adjuvant-induced arthritis in a rat model. BBS4 blocks the formation of the protein-protein interaction present in the dimeric form of iNOS. BBS4 prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice.