4004-05-1
4004-05-1 結(jié)構(gòu)式
基本信息
二油酰基磷脂酰乙醇胺
陽(yáng)離子脂質(zhì)體DOPE
SIRNA脂質(zhì)體DOPE
二油酰磷脂酰乙醇胺DOPE
DOPE,二油酰磷脂酰乙醇胺
二油?；?L-Α-磷脂酰乙醇胺
L-Α-磷脂酰乙醇胺,二油?；?BR>1,2-二油酰甘油-3-磷酸乙醇胺
二油酰磷脂酰乙醇胺DOPE-艾偉拓供
18:1 PE
PE(18:1(9Z)/18:1(9Z))
COATSOME ME-8181 (DOPE)
L-β,γ-Dioleoyl-α-cephalin
18:1 (Delta9-Cis) PE (DOPE)
Dioleoyl phosphoethanolamine
1,2-Dioleoyl-sn-glycero-3-PE
DIOLEOYL PHOSPHATIDYL ETHANOLAMINE
L-BETA,GAMMA-DIOLEOYL-ALPHA-CEPHALIN
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
在5ml無(wú)水氯仿/甲醇/三乙胺溶劑混合物（4.5:0.5:0.05 v/v）中，用20倍摩爾過量的NHS/EDC（1:1摩爾比）活化6毫克MAL-PEG（3000）-MMP2-COH過夜。在4°C氮?dú)獗Ｗo(hù)下，使活化的MAL-PEG（3000）-MMP2-NHS與10倍摩爾過量的DOPE反應(yīng)2小時(shí)。使用氯仿/甲醇（4:1 v/v）作為流動(dòng)相，在制備型鋁TLC板（硅膠60 F254，20 x 20 cm，Merck）上純化反應(yīng)。純化冷凍干燥的殘留物，并在?20°C下儲(chǔ)存，以獲得產(chǎn)品1，2-二油酰-SN-甘油-3-磷酰乙醇胺。
IC50: helper lipid for liposome
In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent).With the neutral lipid for the LNP is DOPE , LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity.LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells.LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs.
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-112005 | 1,2-二油酰-SN-甘油-3-磷酰乙醇胺 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine | 4004-05-1 | 100mg | 1200元 |
| 2024/08/19 | HY-112005 | 1,2-二油酰-SN-甘油-3-磷酰乙醇胺 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine | 4004-05-1 | 250mg | 2450元 |
| 2024/08/19 | HY-112005 | 1,2-二油酰-SN-甘油-3-磷酰乙醇胺 DOPE | 4004-05-1 | 1 g | 3400元 |