400090-20-2
400090-20-2 結構式
基本信息
中文別名
促進成骨肽 英文別名
AC-100Dentonin
Dentonin (AC-100)
L-Aspartic acid, L-threonyl-L-α-aspartyl-L-leucyl-L-glutaminyl-L-α-glutamyl-L-arginylglycyl-L-α-aspartyl-L-asparaginyl-L-α-aspartyl-L-isoleucyl-L-seryl-L-prolyl-L-phenylalanyl-L-serylglycyl-L-α-aspartylglycyl-L-glutaminyl-L-prolyl-L-phenylalanyl-L-lysyl-
所屬類別
生物化工：多肽常見問題列表
生物活性
Dentonin (AC-100) 是 MEPE 來源的短肽片段。Dentonin 通過促進骨祖細胞粘附而促進成骨作用，并且可以促進未成熟的貼壁細胞存活。Dentonin 對成熟成骨細胞無顯著影響。Dentonin 可用于磷酸鹽穩(wěn)態(tài)和骨代謝的研究。體外研究
MEPE is a a member of the SIBLING (Small Integrin-Binding Ligand, N-linked Glycoprotein) family of secreted glycophosphoproteins.? MEPE ?regulates bone mass and influence osteoblast activity..Dentonin (3-30 μg/ml; 2-24 hours) significantly increases the numbers of cell and shows enhanced promotion of cell adhesion. However, it has no significant differences in terms of numbers of cells adhered.Dentonin (3-30 μg/ml; 2-24 hours) enhances osteoblast spreading, it exhibits significantly increased cell areas compared to all other treatment.