394694-98-5
中文名稱
3-氟-N'-((5-硝基噻吩-2-基)亞甲基)苯甲酰肼
英文名稱
3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide
CAS
394694-98-5
分子式
C12H8FN3O3S
分子量
293.27
MOL 文件
394694-98-5.mol
更新日期
2024/11/05 13:11:12
394694-98-5 結(jié)構(gòu)式
基本信息
中文別名
化合物MITOBLOCK-103-氟-N'-((5-硝基噻吩-2-基)亞甲基)苯甲酰肼
英文別名
MB-10MitoBloCK-10 (MB-10)
3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m
3-Fluoro-N'-((5-nitrothiophen-2-yl)methylene)benzohydrazide
3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide
Benzoic acid, 3-fluoro-, 2-[(5-nitro-2-thienyl)methylene]hydrazide
Mitochondrial,Protein,Tim44,MitoBloCK10,MitoBloCK 10,MitoBloCK-10,inhibit,Inhibitor,Import
物理化學(xué)性質(zhì)
密度1.47±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
酸度系數(shù)(pKa)11.21±0.46(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
常見問題列表
生物活性
MitoBloCK-10 (MB-10) 是首個減弱 PAM 復(fù)合體活性的小分子調(diào)節(jié)劑。MitoBloCK-10 (MB-10) 可抑制 C 末端結(jié)構(gòu)域的 Tim44 與前體和 Hsp70 結(jié)合。體外研究
MB-10 (100 μM) is a potential attenuator of protein import into mitochondria.
MB-10 inhibits the import of substrates that use the TIM23 import pathway.
MB-10 (0-100 μM) inhibits protein import into mammalian mitochondria.
Cell Viability Assay
| Cell Line: | A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains. |
| Concentration: | 100 μM. |
| Incubation Time: | 30 min. |
| Result: | WT strain expressing Su9-Ura3 failed to grow, whereas the tim23-2 mutant expressing Su9-Ura3 grew much faster. The strains grew at a similar rate when the medium was supplemented with uracil. |
Cell Viability Assay
| Cell Line: | HeLa cells. |
| Concentration: | 0-100 μM. |
| Incubation Time: | 24 h. |
| Result: | Inhibited HeLa cells vibility, with an IC 50 of 17.2 μM. |