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39379-15-2

中文名稱 神經(jīng)降壓素
英文名稱 NEUROTENSIN
CAS 39379-15-2
分子式 C78H121N21O20
分子量 1672.92
MOL 文件 39379-15-2.mol
更新日期 2024/12/22 20:23:43
39379-15-2 結(jié)構(gòu)式 39379-15-2 結(jié)構(gòu)式

基本信息

中文別名
神經(jīng)降壓素?, >97%
英文別名
NEUROTENSIN
PYR-LYENKPRRPYIL
NEUROTENSIN (1-13)
NEUROTENSIN, BOVINE
M.W. 1672.92 C78H121N21O20
NEUROTENSIN (HUMAN, BOVINE, CANINE)
NEUROTENSIN (HUMAN, BOVINE, CANINE) 2ACOH 6H2O
PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU
GLP-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU
PGLU-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU

物理化學(xué)性質(zhì)

RTECS號QQ4482000
儲存條件Desiccate at -20°C
溶解度insoluble in EtOH; ≥15.33 mg/mL in DMSO; ≥22.55 mg/mL in H2O
形態(tài)凍干粉。
顏色White to off-white
水溶解性Soluble to 0.70 mg/ml in water
序列Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH
神經(jīng)降壓素價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-P0234神經(jīng)降壓素
Neurotensin
39379-15-21mg500元
2024/11/08HY-P0234神經(jīng)降壓素
Neurotensin
39379-15-25mg1500元
2024/11/08HY-P0234神經(jīng)降壓素
Neurotensin
39379-15-210mg2100元

常見問題列表

生物活性
Neurotensin 是一種腸十三肽,作為有效的細(xì)胞有絲分裂原,作用于各種結(jié)腸直腸癌和胰腺癌,對神經(jīng)降壓素受體 (neurotensin receptor,NTR) 具有高親和力。
靶點(diǎn)

Neurotensin receptors (NTR)

體外研究

Neurotensin induces the expression of MIP-2, MCP-1, IL-1β and TNFα in murine microglial cells and stimulates IL-8 secretion in a non-transformed colon epithelial cell line stably transfected with the NTR. The high-affinity NTR, a member of the G-protein coupled receptor (GPCR) family, is present in a majority of human pancreatic and colorectal cancers, suggesting that Neurotensin (NT) may act in an endocrine fashion to affect tumor growth. Acting through the NTR1, Neurotensin is known to stimulate various signal transduction pathways, including intracellular calcium ([Ca 2+ ] i ), the mitogen-activated protein kinases (MAPKs), ERK and JNK, and various PKC isoforms. Treatment of HCT116 cells with Neurotensin (100 nM) significantly increases HCT116 cell migration (~3-fold) compared with vehicle treatment; pretreatment with Curcumin (10 μM) blocksthe stimulatory effect of NT on HCT116 cell migration. ctivation of MEK/ERK by NT and downstream induction of AP-1 transcription factors contributes to the proliferative effects of Neurotensin.

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