38241-28-0
中文名稱
Zinterol hydrochloride
英文名稱
Zinterol hydrochloride
CAS
38241-28-0
分子式
C19H27ClN2O4S
分子量
414.947
MOL 文件
38241-28-0.mol
更新日期
2023/03/20 15:41:23
38241-28-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T26350 英文別名
MJ-9184-1Zinterol HCl
Zinterol hydrochloride
Zinterol hydrochloride >=98% (HPLC)
N-[5-[2-[(1,1-dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]-Methanesulfonamide Hydrochloride
Zinterol hydrochloride價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-14304A | Zinterol hydrochloride Zinterol hydrochloride | 38241-28-0 | 1mg | 1550元 |
| 2024/11/08 | HY-14304A | Zinterol hydrochloride Zinterol hydrochloride | 38241-28-0 | 10 mM * 1 mLin DMSO | 4245元 |
| 2024/11/08 | HY-14304A | Zinterol hydrochloride Zinterol hydrochloride | 38241-28-0 | 5mg | 4650元 |
常見問題列表
生物活性
Zinterol hydrochloride (MJ 9184 hydrochloride) 是一種有效的選擇性 β2-腎上腺素受體 (β2-adrenoceptor) 激動劑。Zinterol hydrochloride 增強(qiáng) ICa，EC50 為 2.2 nM。Zinterol hydrochloride 誘發(fā)清醒心力衰竭家兔室性心律失常。靶點(diǎn)
β2-adrenoceptor
體內(nèi)研究
Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits.
| Animal Model: | In New Zealand White HF rabbits of either sex |
| Dosage: | 1.0 or 2.5 μg/kg |
| Administration: | Intravenous bolus administration; over 5 seconds |
| Result: |
2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits.
2.5 μg/kg led to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits. |