36913-39-0
中文名稱
1-甲基-4-苯基吡啶離子
英文名稱
MPP+ IODIDE
CAS
36913-39-0
分子式
C12H12IN
分子量
297.135
MOL 文件
36913-39-0.mol
更新日期
2024/10/23 11:53:07
36913-39-0 結(jié)構(gòu)式
基本信息
中文別名
MPP+碘MPP+碘化物
MPTP代謝物
1-甲基-4-苯基吡啶
1-甲基-4-苯基吡啶離子
N-甲基-4-苯基吡啶碘化物
1-甲基-4-苯基吡啶碘化物
1-甲基-4-苯基吡啶鎓碘化物
N-甲基-4-苯基吡啶鎓碘化物
碘化-N-甲基-4-苯基吡啶鹽
英文別名
4-phenylpyridin-1-ium iodide1-methyl-4-phenylpyridin-1-ium
MPP+ IODIDE ISO 9001：2015 REACH
1-methyl-4-phenyl-pyridiniuiodide
N-Methyl-4-phenylpyridinium iodide
1-Methyl-4-phenylpyridin-1-iuM iodide
Pyridinium, 1-methyl-4-phenyl-, iodide
MPP+ iodide,1-Methyl-4-phenylpyridinium iodide
MPP+ IODIDE (ACTIVE METABOLITE OF DOPAMI NERGIC NEUROTOX
所屬類別
有機(jī)原料：烴類鹵化物物理化學(xué)性質(zhì)
熔點(diǎn)166-168 °C
儲(chǔ)存條件desiccated
溶解度0.1 M HCl: soluble
形態(tài)solid
顏色yellow
InChIKeyRFDFRDXIIKROAI-UHFFFAOYSA-M
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301+H311+H331-H315-H319-H335
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼23/24/25-36/37/38-25
安全說(shuō)明26-36-45
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 2
WGK Germany3
RTECS號(hào)UU6580000
常見(jiàn)問(wèn)題列表
生物活性
MPP+ iodide 是神經(jīng)毒素 MPTP 的一種有毒代謝物，通過(guò)選擇性破壞黑質(zhì)多巴胺能神經(jīng)元，在動(dòng)物模型中引起帕金森病癥狀。MPP+ iodide 被多巴胺轉(zhuǎn)運(yùn)體吸收進(jìn)入多巴胺能神經(jīng)元，通過(guò)影響呼吸鏈復(fù)合體 I 對(duì)線粒體發(fā)揮神經(jīng)毒性作用。MPP+ iodide 也是 5-羥色胺轉(zhuǎn)運(yùn)體 (SERT) 的高親和力底物。體外研究
MPP+ (1-3 mM; 24 hours) remarkably decreases the viability of cells.
MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity.
Cell Viability Assay
| Cell Line: | SH-SY5Y cells |
| Concentration: | 1, 2, 3 mM |
| Incubation Time: | 24 hours |
| Result: | SH-SY5Y cells were treated with MPP+, mimicking the progress of dopaminergic neurons loss in PD; Reduced cell viability in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner. |