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364762-86-7

中文名稱 TD-198946
英文名稱 TD-198946
CAS 364762-86-7
分子式 C27H22N4O3S
分子量 482.55
MOL 文件 364762-86-7.mol
更新日期 2024/11/08 11:24:22
364762-86-7 結構式 364762-86-7 結構式

基本信息

中文別名
化合物TD198946
TD-198946 (1-METHYL-8-[4-(2-QUINOLINYLMETHOXY)PHENOXY]-4,5-DIHYDRO-1H-THIENO [3,4-G]INDAZOLE-6-CARBOXAMIDE)
英文別名
TD-198946
TD-198946, >98%
TD198946
TD 198946
1-(3-PYRIDINYLMETHYL)-4-PIPERIDINOL DIHYDROCHLORIDE
4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-1H-thieno[3,4-g]indazole-6-carboxamide
1-Methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-4,5-dihydro-1H-thieno [3,4-g]indazole-6-carboxamide
1H-Thieno[3,4-g]indazole-6-carboxamide, 4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-
TD-198946 (1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-4,5-dihydro-1h-thieno [3,4-g]indazole-6-carboxamide)

物理化學性質

沸點699.5±55.0 °C(Predicted)
密度1.43±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(pKa)15.87±0.20(Predicted)
形態(tài)Solid
顏色White to light yellow
TD-198946價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2024/11/08HY-15642TD-198946
TD-198946
364762-86-71mg1142元
2024/11/08HY-15642TD-198946
TD-198946
364762-86-75mg2200元
2024/11/08HY-15642TD-198946
TD-198946
364762-86-710mM * 1mLin DMSO2420元

常見問題列表

生物活性
TD-198946是一種噻吩并唑衍生物。它是一種高效的軟骨形成劑。
體外研究

TD-198946 is a potent chondrogenic agent. TD-198946 strongly induces chondrogenic differentiation without promoting hypertrophy in cell and metatarsal organ cultures. TD-198946 induces stronger Col2a1 promoter activity than insulin in ATDC5 cells. In C3H10T1/2 cells, ATDC5 cells and primary mouse chondrocytes, TD-198946 dose-dependently stimulates endogenous expression of the chondrocyte markers Col2a1 and Acan , with maximum effects around 1-10 μM.

體內研究

When administered directly into the joint space, TD-198946 successfully prevents and repaires degeneration of the articular cartilage. TD-198946 exerts its effect through the regulation of Runx1 expression, which is downregulated in both mouse and human OA cartilage compared with normal tissue. TD-198946 has disease-modifying effects on progressed osteoarthritis. TD-198946 may prevent the progression of osteoarthritis by acting on the remaining chondrocytes rather than repairing damaged cartilage, it may be most effective as a therapeutic during the early or middle stages of osteoarthritis, before the articular cartilage is fully eroded. Cartilaginous cell-sheets are generated by culturing mouse and canine costal chondrocytes and human mesenchymal stem cells with TD-198946 on temperature-responsive dishes. The transplanted cell-sheets are then successfully used to promote the reconstruction of permanent cartilage, with no evidence of chondrocyte hypertrophy in the knee articular cartilage defects created in mice and canines.

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