364762-86-7
基本信息
TD-198946 (1-METHYL-8-[4-(2-QUINOLINYLMETHOXY)PHENOXY]-4,5-DIHYDRO-1H-THIENO [3,4-G]INDAZOLE-6-CARBOXAMIDE)
TD-198946, >98%
TD198946
TD 198946
1-(3-PYRIDINYLMETHYL)-4-PIPERIDINOL DIHYDROCHLORIDE
4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-1H-thieno[3,4-g]indazole-6-carboxamide
1-Methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-4,5-dihydro-1H-thieno [3,4-g]indazole-6-carboxamide
1H-Thieno[3,4-g]indazole-6-carboxamide, 4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-
TD-198946 (1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-4,5-dihydro-1h-thieno [3,4-g]indazole-6-carboxamide)
物理化學性質
報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | HY-15642 | TD-198946 TD-198946 | 364762-86-7 | 1mg | 1142元 |
2024/11/08 | HY-15642 | TD-198946 TD-198946 | 364762-86-7 | 5mg | 2200元 |
2024/11/08 | HY-15642 | TD-198946 TD-198946 | 364762-86-7 | 10mM * 1mLin DMSO | 2420元 |
常見問題列表
TD-198946 is a potent chondrogenic agent. TD-198946 strongly induces chondrogenic differentiation without promoting hypertrophy in cell and metatarsal organ cultures. TD-198946 induces stronger Col2a1 promoter activity than insulin in ATDC5 cells. In C3H10T1/2 cells, ATDC5 cells and primary mouse chondrocytes, TD-198946 dose-dependently stimulates endogenous expression of the chondrocyte markers Col2a1 and Acan , with maximum effects around 1-10 μM.
When administered directly into the joint space, TD-198946 successfully prevents and repaires degeneration of the articular cartilage. TD-198946 exerts its effect through the regulation of Runx1 expression, which is downregulated in both mouse and human OA cartilage compared with normal tissue. TD-198946 has disease-modifying effects on progressed osteoarthritis. TD-198946 may prevent the progression of osteoarthritis by acting on the remaining chondrocytes rather than repairing damaged cartilage, it may be most effective as a therapeutic during the early or middle stages of osteoarthritis, before the articular cartilage is fully eroded. Cartilaginous cell-sheets are generated by culturing mouse and canine costal chondrocytes and human mesenchymal stem cells with TD-198946 on temperature-responsive dishes. The transplanted cell-sheets are then successfully used to promote the reconstruction of permanent cartilage, with no evidence of chondrocyte hypertrophy in the knee articular cartilage defects created in mice and canines.