363600-92-4
中文名稱
TLR2-IN-C29
CAS
363600-92-4
分子式
C16H15NO4
分子量
285.29
MOL 文件
363600-92-4.mol
更新日期
2024/11/05 13:11:14
363600-92-4 結(jié)構(gòu)式
基本信息
中文別名
化合物C293-((2-羥基-3-甲氧基亞芐基)氨基)-2-甲基苯甲酸
英文別名
R2-IN-C29TLR2-IN-C29
C29
C 29
C-29
Benzoic acid, 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-
物理化學(xué)性質(zhì)
沸點(diǎn)505.7±50.0 °C(Predicted)
密度1.21±0.1 g/cm3(Predicted)
儲(chǔ)存條件Inert atmosphere,Store in freezer, under -20°C
酸度系數(shù)(pKa)4.01±0.10(Predicted)
TLR2-IN-C29價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | S6597 | TLR2-IN-C29 TLR2-IN-C29 | 363600-92-4 | 5mg | 1170元 |
| 2024/08/19 | S6597 | TLR2-IN-C29 | 363600-92-4 | 10mM (1mL in DMSO) | 1285.83元 |
| 2024/08/19 | S6597 | TLR2-IN-C29 TLR2-IN-C29 | 363600-92-4 | 25mg | 3970元 |
常見(jiàn)問(wèn)題列表
生物活性
TLR2-IN-C29 (C29)是一種 Toll-like receptor 2 (TLR2) 的抑制劑，可抑制TLR2/1和TLR2/6的信號(hào)傳導(dǎo)。靶點(diǎn)
| Target | Value |
|
TLR2
() |
體外研究
C29 (10 or 50 μΜ; 1 hour) blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 (50-200 μM; 1 hour) inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation in THP-1 cells.
C29 (25 or 50 μΜ; 1 hour) reduces P3C-induced but not P2C-induced TNF-α mRNA and IL-12 p40 protein significantly in primary murine macrophages.
C29 (50 μΜ; 1 hour) blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 cells and murine macrophages.
Western Blot Analysis
| Cell Line: | THP-1 cells |
| Concentration: | 150 μM |
| Incubation Time: | 1 hours |
| Result: | Diminished the interaction between endogenous TLR2 and myeloid differentiation primary response gene 88 (MyD88) at 15 and 30 min poststimulation with P3C. |
Western Blot Analysis
| Cell Line: | Murine peritoneal macrophages |
| Concentration: | 50 μM |
| Incubation Time: | 1 hours |
| Result: |
Blocked robust MAPK activation at 30 min and reduced NF-κB activation from 5 to 30 min.
Prevented P3C-induced degradation of IκBα at 15 and 30 min. |