35865-33-9
中文名稱(chēng)
DIANEMYCIN
英文名稱(chēng)
dianemycin
CAS
35865-33-9
分子式
C47H78O14
分子量
867.11
MOL 文件
35865-33-9.mol
35865-33-9 結(jié)構(gòu)式
基本信息
中文別名
獵神霉素KURASOIN
化合物DIANEMYCIN
英文別名
Nsc138320dianemycin
Nanchangmycin free acid
Nanchangmycin >=98% (HPLC)
6-Nonenoic acid, 8-[(2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-hydroxy-2,4',8,10'-tetramethyl-2'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9'-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7'-bi-1,6-dioxaspiro[4.5]dec]-7-yl]-2,4,6-trimethyl-5...
物理化學(xué)性質(zhì)
沸點(diǎn)700.37°C (rough estimate)
密度1.0559 (rough estimate)
折射率1.6130 (estimate)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 155 mg/mL (178.75 mM); Water: < 0.1 mg/mL (insoluble)
酸度系數(shù)(pKa)4.59±0.21(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
Dianemycin (Nanchangmycin free acid) 由 Streptomyces nanchangensis NS3226 產(chǎn)生的一種聚醚抗生素，抑制革蘭氏陽(yáng)性菌。Nanchangmycin 也是一種抗 Zika 病毒的廣譜抗病毒藥物。靶點(diǎn)
Bacteria
Zika virus
體外研究
Dianemycin (Nanchangmycin) can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Dianemycin is active against drug resistant strains of malaria.
Dianemycin (Nanchangmycin) as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Dianemycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC
50
s for infection are between 0.1 and 0.4 μM while Dianemycin has low toxicity in these ranges. In addition, DENV is inhibited by Dianemycin across cell types.