352336-36-8
中文名稱
MLS000544460
英文名稱
MLS000544460
CAS
352336-36-8
分子式
C17H12FN3O2S
分子量
341.36
MOL 文件
352336-36-8.mol
352336-36-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T12080 英文別名
MLS000544460MLS-000544460,MLS000544460
Benzoic acid, 3-fluoro-, 2-[[5-(2-pyridinylthio)-2-furanyl]methylene]hydrazide
物理化學(xué)性質(zhì)
密度1.33±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)11.31±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
MLS000544460 是一種高度選擇性和可逆的 Eya2 磷酸酶抑制劑，Kd 為 2.0 μM，IC50 為 4 μM。MLS000544460 抑制 Eya2 磷酸酶介導(dǎo)的細胞遷移，并具有抗癌活性。靶點
Kd: 2.0 μM (Eya2 phosphatase)
IC50: 4 μM (Eya2 phosphatase)
體外研究
MLS000544460 does not bind Eya3 phosphatase (ED).
MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells.
When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg
2+
, it binds MLS000544460 with a higher affinity (K
d
=0.80 μM), indicating that this class of compounds does not require Mg
2+
for its interaction with the Eya2 ED.