350997-39-6
中文名稱
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
英文名稱
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
CAS
350997-39-6
分子式
C9H6Cl2N2OS
分子量
261.13
MOL 文件
350997-39-6.mol
更新日期
2024/11/06 10:25:42
350997-39-6 結(jié)構(gòu)式
基本信息
中文別名
3,4-二氯苯并[B]噻吩-2-甲酰肼 英文別名
OGG1-IN-08OGG1-IN-O8
O8 OGG1 Inhibitor
OGG1 Inhibitor O8
OGG1 Inhibitor O8 >=98% (HPLC)
3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
物理化學(xué)性質(zhì)
儲(chǔ)存條件2-8°C
溶解度DMF: 5mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL
形態(tài)粉末
顏色白色至米色
常見問題列表
生物活性
OGG1-IN-08 是一種有效的 8-氧鳥嘌呤 DNA 糖基酶-1 (OGG1) 抑制劑，其 IC50 值為 0.22 μM。OGG1-IN-08 降低 OGG1 的糖基化酶和裂解酶活性。靶點(diǎn)
IC50: 0.22 μM (OGG1)
體外研究
OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits?nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), and Fpg (91.74%), respectively.OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control.OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor.