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34973-27-8

中文名稱(chēng) NHC-triphosphate
英文名稱(chēng) NHC-triphosphate
CAS 34973-27-8
更新日期 2023/03/20 15:41:17
分子式 C9H16N3O15P3
分子量 499.16
34973-27-8 結(jié)構(gòu)式 34973-27-8 結(jié)構(gòu)式

基本信息

中文別名
化合物 T19476
英文別名
NHC-triphosphate
NHC triphosphate,NHCtriphosphate
N4 Hydroxycytidine triphosphateQ: What is N4 Hydroxycytidine triphosphate Q: What is the CAS Number of N4 Hydroxycytidine triphosphate

物理化學(xué)性質(zhì)

密度2.52±0.1 g/cm3(Predicted)
儲(chǔ)存條件Store at -20°C, protect from light, stored under nitrogen
酸度系數(shù)(pKa)0.97±0.50(Predicted)
形態(tài)Solid
顏色White to off-white
水溶解性Water: 160 mg/mL (320.54 mM)
NHC-triphosphate價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2023/03/20HY-135867NHC-triphosphate
NHC-triphosphate
34973-27-81 mg4800元

常見(jiàn)問(wèn)題列表

生物活性
NHC-triphosphate 是 NHC (HY-125033) 的活性胞內(nèi)磷酸鹽代謝物 (intracellular metabolite ),以三磷酸鹽的形式存在。NHC-triphosphate 是病毒聚合酶 (viral polymerase) 的弱底物替代物,會(huì)被并入 HCV 復(fù)制子 RNA 中。
體外研究

In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3 H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono-, di-, and triphosphate forms, and NHC-TP reaches up to 71.12 pM after 8 hours.NHC-triphosphate (NHC-TP) (5-40 μM) absence leads to full-length polymerization products, it can be a weak alternative substrate. In addition, incorporation of NHC-TP instead of CTP increases the molecular weight of the polymerization product by 16 (one extra oxygen) for each event and an obvious electrophoretic shift is observed in cell-free HCV NS5B polymerization reactions.Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC. Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP) can be observed, while NHC-triphosphate (HY-135867) remains the most abundant metabolite.NHC-triphosphate (NHC-TP) metabolite may directly target the viral polymerase and behave as a nonobligate chain terminator.?It plays a prominent role in inhibiting early negative-strand RNA synthesis, either through chain termination or mutagenesis, which may in turn interfere with correct replicase complex formation.

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