34701-53-6
中文名稱
因香酚乙酸酯
英文名稱
Incensole acetate
CAS
34701-53-6
分子式
C22H36O3
分子量
348.52
MOL 文件
34701-53-6.mol
更新日期
2023/03/20 15:41:23
34701-53-6 結(jié)構(gòu)式
基本信息
中文別名
乙酸茵乙酰因香酚
醋酸因香酚
因香酚乙酸酯
醋酸因香酚(因香酚乙酸酯)
英文別名
Insencol AcetateAcetyl incensole
Incensole acetate
(1R,2S,5E,9E,12S)-rel-1,5,9-Trimethyl-12-(1-methylethyl)-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-ol 2-acetate
15-Oxabicyclo[10.2.1]pentadeca-5,9-dien-2-ol, 1,5,9-trimethyl-12-(1-methylethyl)-, 2-acetate, (1R,2S,5E,9E,12S)-
所屬類別
生物化工：植物提取物物理化學(xué)性質(zhì)
沸點(diǎn)420.1±45.0 °C(Predicted)
密度0.99±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF:25.0(Max Conc. mg/mL);71.73(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);71.73(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);71.73(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);71.73(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);71.73(Max Conc. mM)
形態(tài)液體
顏色透明油狀
水溶解性微溶于水
常見問題列表
生物活性
Incensole acetate是卡氏乳香樹脂的主要成分，對(duì)創(chuàng)傷性和缺血性顱腦損傷中的神經(jīng)元損傷具有神經(jīng)保護(hù)作用。Incensole acetate 減少了 hOBNSC 中由 Aβ 25-35 觸發(fā)的細(xì)胞凋亡(apoptosis)。體外研究
Incensole acetate (100 μM; pre-treatment 4 hours) significantly ameliorates Aβ 25–35-induced cell death, a 48–52% decrease in cell viability at Aβ25–35 is restored to 85–89% upon pre-treatment with IA. Incensole acetate (5-100 μM) pretreatment reverses increase in the mRNA and protein level of Bax, caspase 8, cyto c and decrease in the mRNA and protein level of Bcl2 induced by Aβ 25–35 in hOBNSCs.
Cell Viability Assay
| Cell Line: | Human olfactory bulb neural stem cells |
| Concentration: | 100 μM |
| Incubation Time: | Pre-treatment 4 hours |
| Result: | Increased hOBNSCs cell viability induced by Aβ 25-35. |