32350-57-5
中文名稱
R-Stearoyl Carnitine Chloride
英文名稱
R-Stearoyl Carnitine Chloride
CAS
32350-57-5
分子式
C25H48ClNO3
分子量
446.107
MOL 文件
32350-57-5.mol
更新日期
2024/11/26 09:31:12
32350-57-5 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
熔點(diǎn)>158°C (dec.)
儲(chǔ)存條件Refrigerator
溶解度DMSO (Slightly, Heated), Methanol (Slightly)
形態(tài)Solid
顏色White to Off-White
常見問題列表
生物活性
Stearoyl-L-carnitine chloride 是一種內(nèi)源性的長(zhǎng)鏈?；鈮A。Stearoyl-L-carnitine chloride 是一種效力較弱的 GlyT2 抑制劑。Stearoyl-L-carnitine chloride 在濃度高達(dá) 3 μM 時(shí)可抑制 16.8％ 的甘氨酸響應(yīng)。靶點(diǎn)
|
GlyT2
|
體外研究
Stearoyl-L-carnitine (0.01-10 μM) inhibits glycine (30 μM) transports by 16.8% at concentrations up 3 μM in
Xenopus laevis
oocytes.
Stearoyl-L-carnitine (500 μM; 30 min) inhibits Na
+
-dependent [
3
H]carnitine (20 nM) uptake by ~50% in HPCT cells.
體內(nèi)研究
Stearoyl-L-carnitine is significantly decreased in Alzheimer's disease (AD), mild cognitive impairment (MCI) and subjective memory complaint (SMC).