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3102-57-6

中文名稱 N-乙?;窠?jīng)鞘氨醇
英文名稱 C2 CERAMIDE
CAS 3102-57-6
分子式 C20H39NO3
分子量 341.53
MOL 文件 3102-57-6.mol
更新日期 2023/07/07 14:14:28
3102-57-6 結構式 3102-57-6 結構式

基本信息

中文別名
N-乙?;窠?jīng)鞘氨醇
英文別名
CERAMIDE
CERAMIDE C2
C2 CERAMIDE
C2:0 CERAMIDE
TOC Ceramide
ACETYL CERAMIDE
C14 SPHINGOID BASE
N-ACETYLSPHINGOSINE
C2-D-ERYTHRO-CERAMIDE
N-ACETYL-D-SPHINGOSINE
所屬類別
生物化工:生化試劑

物理化學性質(zhì)

熔點93-96 °C
熔點93-96 °C
沸點477.13°C (rough estimate)
密度1.0283 (rough estimate)
折射率1.5614 (estimate)
儲存條件−20°C
儲存條件−20°C
溶解度DMSO: soluble
溶解度可溶于DMSO
酸度系數(shù)(pKa)13.50±0.20(Predicted)
形態(tài)powder
顏色white
穩(wěn)定性濕氣敏感

安全數(shù)據(jù)

安全說明22-24/25
WGK Germany3
WGK Germany3
海關編碼29241990

常見問題列表

生物活性
C2 Ceramide (Ceramide 2) 是一種角質(zhì)層的主要脂質(zhì),也是一種蛋白質(zhì)磷酸酶 1 (PP1) 的激活劑。C2 Ceramide 還可激活 PP2A 和神經(jīng)酰胺激活的蛋白磷酸酶 (CAPP)。C2 Ceramide 可誘導細胞分化和凋亡 (apoptosis),抑制線粒體呼吸鏈復合物 III (mitochondrial respiratory chain complex III)。C2 Ceramide 是一種皮膚調(diào)理劑,可保護表皮屏障免受水分流失。
靶點

Protein phosphatase 1
PP2A
Ceramide-activated protein phosphatase (CAPP)
Apoptosis
Mitochondrial respiratory chain complex III

體外研究

C2 Ceramide (5 nM-200 μM; 24 hours; primary mouse osteoblasts) treatment (≤500 nM) promots osteoblast viability, whilst concentrations ≥2 μM significantly reduces osteoblast viability in a dose- and time-dependent manner.
C2 Ceramide increases cytoplasmic histone-associated DNA fragments by 5.7- and 11.2-fold at 50 μM and 100 μM C2 Ceramide concentrations respectively in osteoblasts. At these higher concentrations, C2 Ceramide is a potent inducer of apoptosis in osteoblasts.
C2 Ceramide up-regulates mRNA expression of angiogenic genes in human dental pulp cells (HDPCs) and increases the migration and capillary tube formation of endothelial cells, whereas PP1 small interfering RNA shows opposite effects. Human dental pulp cells (HDPCs) increases levels of bone morphogenetic protein 2, phosphorylation of Smad 1/5/8, and mRNA expression of runt-related transcription factor 2 and osterix.

Cell Viability Assay

Cell Line: Primary mouse osteoblasts
Concentration: 5 nM-200 μM
Incubation Time: 24 hours
Result: Murine osteoblasts demonstrated a dose-dependent increase in their survival rate when exposed to low concentrations of 5-500 n?M. Increasing concentrations of 20-200μM caused a dose-dependent decrease in mitochondrial succinate dehydrogenase activity and osteoblast survival.
體內(nèi)研究

The PP1 activator C2 Ceramide increases alkaline phosphatase activity, mineralizes nodule formation, and mRNA expression of dentin matrix protein 1 and dentin sialophosphoprotein. In contrast, knockdown by PP1 small interfering RNA inhibits odontoblastic differentiation.

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