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30344-00-4

中文名稱 對(duì)稱N,N-二甲基精氨酸
英文名稱 N,N'-Dimethylarginine
CAS 30344-00-4
分子式 C8H18N4O2
分子量 202.25
MOL 文件 30344-00-4.mol
更新日期 2024/08/13 16:09:49
30344-00-4 結(jié)構(gòu)式 30344-00-4 結(jié)構(gòu)式

基本信息

中文別名
對(duì)稱性二甲基精氨酸
對(duì)稱N,N-二甲基精氨酸
對(duì)稱N,N'-二甲基精氨酸溶液,100PPM
(S)-2-氨基-5-((雙(甲基氨基)亞甲基)氨基)戊酸
NG,NG′-二甲基-L-精氨酸二(對(duì)羥基偶氮苯-P'-磺酸鹽)鹽
英文別名
SDMA-d6
NG'-Dimethyl-L-arginine
Symmetric dimethylarginine
Nω,N'ω-dimethyl-L-arginine
NG,NG’-Dimethy-L-arginine-d6
L-Arg(Me, Me)-OH (syMMetrical)
L-Arg(Me, Me)-OH (asyMMetrical)
N,N'-Dimethylarginine USP/EP/BP
L-Arg(Me,Me)-OH(symmetrical), >97%
NG,NG'-Dimethy-L-arginine Solution, 100ppm
所屬類別
生物化工:精氨酸類衍生物

物理化學(xué)性質(zhì)

沸點(diǎn)353.5±52.0 °C(Predicted)
密度1.22±0.1 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Room temperature
溶解度DMSO : 50 mg/mL (247.22 mM; ultrasonic and adjust pH to 3 with 1M HCl)
酸度系數(shù)(pKa)2.48±0.24(Predicted)
形態(tài)橙色粉末
顏色White to off-white
穩(wěn)定性非常吸濕

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338
對(duì)稱N,N-二甲基精氨酸價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/08/19S5838對(duì)稱N,N-二甲基精氨酸
SDMA
30344-00-45mg795.38元
2024/08/19S5838SDMA30344-00-410mM (1mL in DMSO)1040.13元
2024/08/19S5838對(duì)稱N,N-二甲基精氨酸
SDMA
30344-00-425mg2212.11元

常見(jiàn)問(wèn)題列表

生物活性
SMDA (symmetric dimethylarginine)是精氨酸的甲基化形式,存在于所有的有核細(xì)胞中,在蛋白質(zhì)水解后被釋放到循環(huán)體統(tǒng)中,通過(guò)腎臟排泄,在人、犬類和貓中與腎小球?yàn)V過(guò)率相關(guān)。
靶點(diǎn)

Human Endogenous Metabolite

體外研究

SDMA is the structural isomer of the cardiovascular risk marker asymmetric dimethylarginine, as an endogenous marker of renal function. SDMA does not directly inhibit NOS but is a competitor of arginine transport. SDMA is primarily eliminated by renal excretion and is a promising endogenous marker of glomerular filtration rate. SDMA inhibits dose dependently the NO synthesis in intact endothelial cells, whereas it has no effect on protein expression of NOS. SDMA is involved in the inflammatory process of chronic kidney disease, activating NF-κB and resulting in enhanced expression of IL-6 and TNF-α.

體內(nèi)研究

SDMA is highly stable in serum and plasma, and the assay demonstrates excellent analytical performance. In unaffected dogs, SDMA remains unchanged whereas in affected dogs, SDMA increases during disease progression, correlating strongly with an increase in sCr and decrease in GFR. Chronic SDMA infusion leads to a significant increase of SDMA levels in mice, but the GFR did not change at 4 weeks. No histological changes are observed, particularly no effect on fibrosis or endothelias nitric oxide synthase expression. There is neither an effect of SDMA on systolic blood pressure nor on ejection fraction.

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