289483-69-8
289483-69-8 結構式
基本信息
血管生成抑制劑(E7820)
CS-2701
ER 68203-00
E 7820
E-7820
ER68203-00
E7820
E-7820
E 7820
289483-69-8
3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide
N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide
Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-
物理化學性質
常見問題列表
E7820 (ER68203-00) inhibits both bFGF- and VEGF-driven ube formation of human umbilical vascular endothelial cell (HUVEC) in a dose-dependent manner with IC
50
of 0.20 and 0.24 μg/ml, respectively.
E7820 inhibits proliferation of HUVEC induced by either bFGF or VEGF in serum-free medium (SFM). The IC
50
values are 0.10 and 0.081 μg/ml, respectively. Antiproliferative activity of E7820 against both WiDr and LoVo cells is very weak compared with that against HUVEC. The values of IC50 were 29 and 15 μg/ml, respectively.
E7820 (ER68203-00) (50-200 mg/kg; p.o. ; twice daily for 14 days) delays the growth of WiDr cells inoculated s.c..
E7820 (200-400 mg/kg; p.o.;once daily for 4 days) potently inhibits WiDr-induced angiogenesis.
| Animal Model: | Six-week-old female nude mice (KSN mice, WiDr-induced angiogenesis model) |
| Dosage: | 50, 100, 200 mg/kg |
| Administration: | p.o. ; twice daily for 14 days from 2 days after inoculation of the tumor cells |
| Result: | The antitumor effect was dose-dependent at 50, 100, and 200 mg/kg, and the tumor growth rates were 52%, 46%, and 27%, respectively. |