285986-31-4
中文名稱
STAT5 Inhibitor
英文名稱
STAT5 Inhibitor
CAS
285986-31-4
分子式
C16H11N3O3
分子量
293.28
MOL 文件
285986-31-4.mol
更新日期
2024/11/05 13:11:13
285986-31-4 結(jié)構(gòu)式
基本信息
中文別名
STAT5抑制劑化合物STAT5 INHIBITOR
STAT5抑制劑(STAT5-IN-1)
英文別名
CS-2509MDK6314
STAT5-IN-1
STAT5 Inhibitor
STAT5 Inhibitor 1
N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide
(E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
3-Pyridinecarboxylic acid, 2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide
所屬類別
生物化工：抑制劑物理化學性質(zhì)
熔點214-216 °C
密度1.33±0.1 g/cm3(Predicted)
儲存條件Keep in dark place,Sealed in dry,2-8°C
溶解度≥9.58 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
酸度系數(shù)(pKa)10.44±0.46(Predicted)
形態(tài)結(jié)晶固體
顏色White to light yellow
STAT5 Inhibitor價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/08/19 | HY-101853 | STAT5 Inhibitor STAT5-IN-1 | 285986-31-4 | 5mg | 550元 |
| 2024/08/19 | HY-101853 | STAT5 Inhibitor STAT5-IN-1 | 285986-31-4 | 10mM * 1mLin DMSO | 605元 |
| 2024/08/19 | S6784 | STAT5 Inhibitor STAT5-IN-1 | 285986-31-4 | 5mg | 557.25元 |
常見問題列表
生物活性
STAT5-IN-1 是一種有效的選擇性 STAT5 抑制劑，其對于STAT5β亞型的IC50值為47 μM。靶點
| Target | Value |
|
STAT5β
(Cell-free assay) | 47 μM |
體外研究
The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 μM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members.