269718-83-4
中文名稱
鹽酸帕多蘆諾
英文名稱
2(3H)-BENZOXAZOLONE, 7-(4-METHYL-1-PIPERAZINYL)-, MONOHYDROCHLORIDE
CAS
269718-83-4
分子式
C12H16ClN3O2
分子量
269.727
MOL 文件
269718-83-4.mol
更新日期
2025/01/07 01:14:28
269718-83-4 結(jié)構(gòu)式
基本信息
中文別名
鹽酸帕多蘆諾帕多蘆諾鹽酸鹽
英文別名
pardoprunox.HClpardoprunox.HCl.H2O
SLV-308 hydrochloride
DU-126891 hydrochloride
Pardoprunox.HCl(SLV-308)
Pardoprunox (hydrochloride)
SLV-308 HYDROCHLORIDE
DU-126891 HYDROCHLORIDE
SLV308
SLV 308
2(3H)-BENZOXAZOLONE, 7-(4-METHYL-1-PIPERAZINYL)-, MONOHYDROCHLORIDE
2(3H)-Benzoxazolone,7-(4-methyl-1-piperazinyl)-, hydrochloride (1:1)
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
儲(chǔ)存條件Inert atmosphere,2-8°C
溶解度DMSO:5.0(Max Conc. mg/mL);18.5(Max Conc. mM)
形態(tài)結(jié)晶固體
顏色Off-white to pink
鹽酸帕多蘆諾價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-14958A | 鹽酸帕多蘆諾 Pardoprunox hydrochloride | 269718-83-4 | 5mg | 550元 |
| 2024/11/08 | HY-14958A | 鹽酸帕多蘆諾 Pardoprunox hydrochloride | 269718-83-4 | 10 mM * 1 mLin DMSO | 610元 |
| 2024/11/08 | HY-14958A | 鹽酸帕多蘆諾 Pardoprunox hydrochloride | 269718-83-4 | 10mg | 900元 |
常見問題列表
生物活性
Pardoprunox hydrochloride (DU-126891, SME-308)是一種有效的部分 dopamine D2 receptor 的激動(dòng)劑，對(duì)應(yīng)的pEC50值為8.0，也是誘導(dǎo) [35S]GTPγS binding 的部分激動(dòng)劑，對(duì)應(yīng)的pEC50值為9.2，和 serotonin 5-HT1A receptor 的激動(dòng)劑，pEC50值為6.3。靶點(diǎn)
| Target | Value |
|
[
(Cell-free assay) | 9.2(pEC50) |
|
D2 receptor
(Cell-free assay) | 8.0(pEC50) |
|
5-HT1A receptor
(Cell-free assay) | 6.3(pEC50) |
體外研究
Pardoprunox (SLV-308) hydrochloride acts as a potent but partial D2 receptor agonist (pEC 50 = 8.0 and pA 2 =8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox hydrochloride acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC 50 =9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA 2 =9.0). Pardoprunox hydrochloride acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC 50 =6.3).