265646-85-3
中文名稱
ENDOVION
英文名稱
Endovion
CAS
265646-85-3
分子式
C16H9BrF6N6O
分子量
495.18
MOL 文件
265646-85-3.mol
更新日期
2024/11/13 09:55:57
265646-85-3 結(jié)構(gòu)式
基本信息
中文別名
化合物ENDOVION1-(3,5-雙(三氟甲基)苯基)-3-(4-溴-2-(2H-四唑-5-基)苯基)脲
英文別名
NS3728Endovion
NS3728 >=98% (HPLC)
Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-
物理化學(xué)性質(zhì)
密度1.791±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度Soluble to 100 mM in DMSO and to 50 mM in ethanol
酸度系數(shù)(pKa)3.95±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
水溶解性Water : < 0.1 mg/mL (insoluble)
ENDOVION價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-105917 | ENDOVION Endovion | 265646-85-3 | 5mg | 500元 |
| 2024/11/08 | HY-105917 | ENDOVION Endovion | 265646-85-3 | 10mM * 1mLin DMSO | 545元 |
| 2024/11/08 | HY-105917 | ENDOVION Endovion | 265646-85-3 | 10mg | 770元 |
常見問(wèn)題列表
生物活性
Endovion (NS3728) 是一種陰離子通道抑制劑 (如氯離子通道)，也是特異性的 VRAC/VSOAC 阻斷劑。Endovion (NS3728) 還是一種 ANO1 抑制劑。靶點(diǎn)
Chloride channel, VRAC/VSOAC.
ANO1.
體外研究
Endovion (NS3728, 10-100 μM) reduces TNFα-induced apoptosis and increases p53-protein level as well as downstream signaling, e.g., expression of p21
Waf1/Cip1
, Bax, Noxa, MDM2, and activation of Caspase-9/-3 in Cisplatin-sensitive cells.
Endovion (NS3728, 10 μM) inhibits cell proliferation in Capan-1, AsPC-1 and BxPC-3 cell lines.
Western Blot Analysis
| Cell Line: | Wild-type, resistant, and transiently transfected A2780 cells. |
| Concentration: | 10-100 μM. |
| Incubation Time: | 18 or 4.5 h. |
| Result: |
Reduced the maximal taurine rate constant more than 90% compared with the untreated control cells.
Resulted in an increased LRRC8A protein expression. Significantly reduceed p53 and p21Waf1/Cip1 protein level in A2780WT cells. |
Cell Proliferation Assay
| Cell Line: | Capan-1, AsPC-1, BxPC-3 and H6c7 cell lines. |
| Concentration: | 10 μM. |
| Incubation Time: | 24 h. |
| Result: | Resulted in the most pronounced inhibition in all cell lines with 77?±?26 % in Capan-1, 67?±?9 % in AsPC-1, and 54?±?8 % in BxPC-3 cells at +67 mV. |